Increased mortality after kidney transplantation in mildly frail recipients
Pérez-Sáez, María José (Hospital del Mar (Barcelona, Catalunya))
Arias Cabrales, Carlos E (Hospital del Mar (Barcelona, Catalunya))
Redondo-Pachón, Dolores (Hospital del Mar (Barcelona, Catalunya))
Burballa, Carla (Hospital del Mar (Barcelona, Catalunya))
Buxeda, Anna (Hospital del Mar (Barcelona, Catalunya))
Bach Pascual, Anna (Hospital del Mar (Barcelona, Catalunya))
Faura, Anna (Hospital del Mar (Barcelona, Catalunya))
Junyent, Ernestina (Hospital del Mar (Barcelona, Catalunya))
Marco, Ester (Parc de Salut MAR de Barcelona)
Rodríguez-Mañas, Leocadio (Hospital Universitario de Getafe (Madrid))
Crespo, Marta (Hospital del Mar (Barcelona, Catalunya))
Pascual Santos, Julio (Hospital del Mar (Barcelona, Catalunya))
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Physical Frailty Phenotype (PFP) is the most used frailty instrument among kidney transplant recipients, classifying patients as pre-frail if they have 1-2 criteria and as frail if they have ≥3. However, different definitions of robustness have been used among renal patients, including only those who have 0 criteria, or those with 0-1 criteria. Our aim was to determine the impact of one PFP criterion on transplant outcomes. We undertook a retrospective study of 296 kidney transplant recipients who had been evaluated for frailty by PFP at the time of evaluating for transplantation. Only 30. 4% of patients had 0 criteria, and an additional 42. 9% showed one PFP criterion. As PFP score increased, a higher percentage of women and cerebrovascular disease were found. Recipients with 0-1 criteria had lower 1-year mortality after transplant than those with ≥2 (1. 8% vs 10. 1%), but this difference was already present when we only considered those who scored 0 (mortality 1. 1%) and 1 (mortality 2. 4%) separately. The multivariable analysis confirmed that one PFP criterion was associated to a higher risk of patient death after kidney transplantation [hazard ratio 3. 52 (95% confidence interval 1. 03-15. 9)]. Listed kidney transplant candidates frequently show only one PFP frailty criterion. This has an independent impact on patient survival after transplantation.
Ajuts:	Instituto de Salud Carlos III PI19/00037 Instituto de Salud Carlos III CM19/00004
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Frailty phenotype ; Fried ; Survival ; Transplant
Publicat a:	Clinical Kidney Journal, Vol. 15 (june 2022) , p. 2089-2096, ISSN 2048-8513

DOI: 10.1093/ckj/sfac159
PMID: 36325004

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