The Thalamus and its subnuclei-a gateway to obsessive-compulsive disorder
Weeland, Cees J. (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
Kasprzak, Selina (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
de Joode, Niels T. (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
Abe, Yoshinari (Graduate School of Medical Science, Kyoto Prefectural University of Medicine. Department of Psychiatry)
Alonso, Pino (Universitat de Barcelona. Departament de Ciències Clíniques)
Ameis, Stephanie H. (The Hospital for Sick Children. Program in Neurosciences and Mental Health)
Anticevic, Alan (Yale University. Departments of Psychiatry and Neuroscience)
Arnold, Paul D. (University of Calgary. Cumming School of Medicine)
Balachander, Srinivas (National Institute of Mental Health And Neurosciences (NIMHANS). OCD clinic, Department of Psychiatry)
Banaj, Nerisa (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation)
Bargalló, Núria (Hospital Universitari de Bellvitge. Institut de Diagnòstic per la Imatge)
Batistuzzo, Marcelo C. (Pontificial Catholic University of Sao Paulo. Department of Methods and Techniques in Psychology)
Benedetti, Francesco (Division of Neuroscience, IRCCS San Raffaele Scientific Institute. Psychiatry & Clinical Psychobiology)
Beucke, Jan C. (MSH Medical School Hamburg. Institute for Systems Medicine and Faculty of Human Medicine)
Bollettini, Irene (Scientific Institute Ospedale San Raffaele. Psychiatry and Clinical Psychobiology, Division of Neuroscience)
Brecke, Vilde (Haukeland University Hospital. Bergen Center for Brain Plasticity)
Brem, Silvia (University of Zurich and ETH Zurich. Neuroscience Center Zurich)
Cappi, Carolina (Icahn School of Medicine at Mount Sinai Department of Psychiatry)
Cheng, Yuqi (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Cho, Kang Ik K. (Seoul National University College of Natural Science. Department of Brain and Cognitive Sciences)
Costa, Daniel L. C. (Universidade de São Paulo (USP). Obsessive-Compulsive Spectrum Disorders Program, Departamento e Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina)
Dallaspezia, Sara (IRCCS Ospedale San Raffaele, Milano Italy Psychiatry)
Denys, Damiaan (Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience)
Eng, Goi Khia (Nathan Kline Institute for Psychiatric Research. Clinical Research)
Ferreira, Sónia (Clinical Academic Center - Braga)
Feusner, Jamie D. (University of California Los Angeles. Semel Institute for Neuroscience and Human Behavior, Department of Psychiatry and Biobehavioral Sciences)
Fontaine, Martine (Columbia University. Columbia University Medical College)
Fouche, Jean-Paul (University of Cape Town. Department of Psychiatry and Mental Health)
Grazioplene, Rachael G. (Yale University. Department of Psychiatry)
Gruner, Patricia (Yale University. Department of Psychiatry)
He, Mengxin (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Hirano, Yoshiyuki (United Graduate School of Child Development, Osaka University, Kanazawa University, Hamamatsu University School of Medicine, Chiba University and University of Fukui, Suita, Japan)
Hoexter, Marcelo Q. (Universidade de Sao Paulo. Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina)
Huyser, Chaim (Amsterdam UMC, Department of Child and Adolescent Psychiatry)
Hu, Hao (Shanghai Jiao Tong University School of Medicine. Shanghai Mental Health Center)
Jaspers-Fayer, Fern (British Columbia Children's Hospital Research Institute)
Kathmann, Norbert (Humboldt-Universität zu Berlin. Department of Psychology)
Kaufmann, Christian (Humboldt-Universität zu Berlin. Department of Psychology)
Kim, Minah (Seoul National University College of Medicine, Department of Psychiatry)
Koch, Kathrin (Technische Universität München)
Bin Kwak, Yoo (Seoul National University College of Natural Science. Department of Brain and Cognitive Sciences)
Kwon, Jun Soo (Institute of Human Behavioral Medicine, SNU-MRC)
Lazaro, Luisa (Universitat de Barcelona. Departament de Medicina)
Li, Chiang-shan R. (Centro de Investigación Biomédica en Red de Salud Mental)
Lochner, Christine (Stellenbosch University, SAMRC Unit on Risk and Resilience in Mental Disorders, Department of Psychiatry)
Marsh, Rachel (Columbia University. Columbia University Medical College)
Martínez-Zalacaín, Ignacio (Universitat de Barcelona. Departament de Ciències Clíniques)
Mataix-Cols, David (Region Stockholm. Stockholm Health Care Services)
Menchón Magriñá, José Manuel (Universitat de Barcelona. Departament de Ciències Clíniques)
Minnuzi, Luciano (Offord Centre for Child Studies, Hamilton, Ontario Canada)
Moreira, Pedro Silva (University of Minho. Psychological Neuroscience Lab, CIPsi, School of Psychology)
Morgado, Pedro (Hospital de Braga)
Nakagawa, Akiko (Chiba University. Research Center for Child Mental Development)
Nakamae, Takashi (Graduate School of Medical Science Kyoto Prefectural University of Medicine, Department of Psychiatry)
Narayanaswamy, Janardhanan C. (National Institute of Mental Health And Neurosciences (NIMHANS). OCD clinic, Department of Psychiatry)
Nurmi, Erika L. (University of California, Los Angeles. Department of Psychiatry and Biobehavioral Sciences)
Ortiz, Ana E. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Pariente, Jose C. (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Piacentini, John (UCLA Semel Institute, Division of Child and Adolescent Psychiatry)
Picó-Pérez, Maria (Clinical Academic Center - Braga)
Piras, Fabrizio (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation)
Piras, Federica (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation)
Pittenger, Christopher (Yale University. Department of Psychiatry and Yale Child Study Center)
Reddy, Y. C. Janardhan (National Institute of Mental Health And Neurosciences (NIMHANS). OCD clinic, Department of Psychiatry)
Rodriguez-Manrique, Daniela (Ludwig-Maximilians-Universität. Graduate School of Systemic Neurosciences (GSN))
Sakai, Yuki (Department of Neural Computation for Decision-Making, Advanced Telecommunications Research Institute International Brain Information Communication Research Laboratory Group)
Shimizu, Eiji (Chiba University. Research Center for Child Mental Development)
Shivakumar, Venkataram (National Institute of Mental Health and Neurosciences (NIMHANS). Department of Integrative Medicine)
Simpson, Helen Blair (New York State Psychiatric Institute)
Soreni, Noam (Pediatric OCD Consultation Team, Anxiety Treatment and Research Center, Hamilton, Ontario Canada)
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Sousa, Nuno (Clinical Academic Center - Braga)
Spalletta, Gianfranco (Baylor College of Medicine, Department of Psychiatry and Behavioral Sciences)
Stern, Emily R. (Nathan Kline Institute for Psychiatric Research. Clinical Research)
Stevens, Michael C. (Yale University School of Medicine)
Stewart, S. Evelyn (BC Mental Health and Substance Use Services Research Institute)
Szeszko, Philip R. (Mental Illness Research, Education and Clinical Center. James J. Peters VA Medical Center)
Takahashi, Jumpei (Chiba University Hospital. Department of Child Psychiatry)
Tanamatis, Tais (Universidade de Sao Paulo. Departamento de Psiquiatria, Hospital das Clinicas HCFMUSP, Faculdade de Medicina)
Tang, Jinsong (Zhejiang University Medical Center. Liangzhu Laboratory)
Thorsen, Anders Lillevik (University of Bergen. Centre for Crisis Psychology)
Tolin, David (Institute of Living/Hartford Hospital)
van der Werf, Ysbrand D. (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
van Marle, Hein (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
van Wingen, Guido A. (Amsterdam UMC, University of Amsterdam, Department of Psychiatry, Amsterdam Neuroscience)
Vecchio, Daniela (Laboratory of Neuropsychiatry, Department of Clinical and Behavioral Neurology, IRCCS Santa Lucia Foundation)
Venkatasubramanian, Ganesan (National Institute of Mental Health And Neurosciences, Department of Psychiatry)
Walitza, Susanne (University of Zurich and ETH Zurich. Neuroscience Center Zurich)
Wang, Jicai (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Wang, Zhen (Shanghai Jiao Tong University School of Medicine. Shanghai Mental Health Center)
Watanabe, Anri (Graduate School of Medical Science, Kyoto Prefectural University of Medicine. Department of Psychiatry)
Wolters, Lidewij H. (Levvel, Academic Center for Child and Adolescent Psychiatry, Post Box 303, 1115 ZG Duivendrecht, the Netherlands)
Xu, Xiufeng (First Affiliated Hospital of Kunming Medical University. Department of Psychiatry)
Yun, Je-Yeon (Seoul National University College of Medicine. Yeongeon Student Support Center)
Zhao, Qing (Shanghai Jiao Tong University School of Medicine. Shanghai Mental Health Center)
White, Tonya (University of Southern California. Department of Radiology and Nuclear Medicine)
Thompson, Paul M. (University of Southern California. Imaging Genetics Center, Stevens Institute for Neuroimaging & Informatics, Keck School of Medicine)
Stein, Dan J. (University of Cape Town. SAMRC Unit on Risk & Resilience in Mental Disorders, Department of Psychiatry & Neuroscience Institute)
van den Heuvel, Odile A. (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)
Vriend, Chris (Amsterdam UMC, Vrije Universiteit Amsterdam, Department of Psychiatry, Department of Anatomy & Neurosciences)

Data:	2022
Resum:	Larger thalamic volume has been found in children with obsessive-compulsive disorder (OCD) and children with clinical-level symptoms within the general population. Particular thalamic subregions may drive these differences. The ENIGMA-OCD working group conducted mega- and meta-analyses to study thalamic subregional volume in OCD across the lifespan. Structural T-weighted brain magnetic resonance imaging (MRI) scans from 2649 OCD patients and 2774 healthy controls across 29 sites (50 datasets) were processed using the FreeSurfer built-in ThalamicNuclei pipeline to extract five thalamic subregions. Volume measures were harmonized for site effects using ComBat before running separate multiple linear regression models for children, adolescents, and adults to estimate volumetric group differences. All analyses were pre-registered () and adjusted for age, sex and intracranial volume. Unmedicated pediatric OCD patients (<12 years) had larger lateral (d = 0. 46), pulvinar (d = 0. 33), ventral (d = 0. 35) and whole thalamus (d = 0. 40) volumes at unadjusted p -values <0. 05. Adolescent patients showed no volumetric differences. Adult OCD patients compared with controls had smaller volumes across all subregions (anterior, lateral, pulvinar, medial, and ventral) and smaller whole thalamic volume (d = − 0. 15 to −0. 07) after multiple comparisons correction, mostly driven by medicated patients and associated with symptom severity. The anterior thalamus was also significantly smaller in patients after adjusting for thalamus size. Our results suggest that OCD-related thalamic volume differences are global and not driven by particular subregions and that the direction of effects are driven by both age and medication status.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Psychiatric disorders ; Neuroscience
Publicat a:	Translational psychiatry, Vol. 12 (february 2022) , ISSN 2158-3188

DOI: 10.1038/s41398-022-01823-2
PMID: 35190533

10 p, 2.3 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats