Defective involuntary attention to novelty in type 1 diabetes and impaired awareness of hypoglycaemia
Stantonyonge, Nicole (Institut d'Investigació Biomèdica Sant Pau)
Martinez-Horta, Saul (Institut d'Investigació Biomèdica Sant Pau)
Sampedro, Frederic (Institut d'Investigació Biomèdica Sant Pau)
Sánchez-Saudinós, María Belén (Institut d'Investigació Biomèdica Sant Pau)
Chico Ballesteros, Ana (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	Aim: To determine if there are differences in terms of neurophysiology and neurocognitive functioning in a group of type 1 diabetes (T1D) patients regarding hypoglycaemia awareness. Methods: 27 patients with T1D were classified according to Clarke score as having impaired awareness of hypoglycaemia (IAH; n = 11) or normal awareness to hypoglycaemia (NAH; n = 16). We measured several clinical and sociodemographic variables and cognitive performance using neuropsychological tests. Electroencephalography was assessed during an auditory oddball task. We compared the groups in terms of clinical/sociodemographic variables as well as two event-related brain potentials (ERPs): The P3a which is associated with automatic orientation of attention to novelty, and the P3b which is associated with target detection and processing. Results: The IAH group performed significantly worse on the Trail Making Test part A (TMT-A) (p = 0. 05). Compared to the NAH group, P3a and P3b amplitudes in the frontal-central sites were significantly lower in the IAH group (p < 0. 05). The P3a was strongly associated with worse performance on the TMT-A in the IAH group (r = 0. 540; p < 0. 005) Conclusion: IAH is accompanied by decreased neurophysiological activity in ERPs associated with information processing and with the automatic orientation of attention to novelty and environmental changes. These findings suggest a possible framework to better understand the cognitive origin of IAH in this patient population.
Note:	Altres ajuts: Sociedad Española de Diabetes
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Type 1 diabetes ; Hypoglycaemia ; Impaired awareness ; Neurophysiology
Published in:	Diabetes research and clinical practice, Vol. 177 (july 2021) , p. 108898, ISSN 1872-8227

DOI: 10.1016/j.diabres.2021.108898
PMID: 34098058

9 p, 991.3 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles