Different Approaches to Analyze Muscle Fat Replacement With Dixon MRI in Pompe Disease
Alonso-Jiménez, Alicia (University Hospital Antwerp (Bèlgica))
Nuñez Peralta, Claudia Alejandra (Universitat Autònoma de Barcelona)
Montesinos, P. (Philips Healthcare Iberia)
Alonso-Pérez, Jorge (Institut d'Investigació Biomèdica Sant Pau)
García-Sánchez, Carmen (Institut d'Investigació Biomèdica Sant Pau)
Montiel, E. (Universitat Autònoma de Barcelona)
Belmonte Jimeno, Izaskun (Institut d'Investigació Biomèdica Sant Pau)
Pedrosa, Irene (Institut d'Investigació Biomèdica Sant Pau)
Segovia, Sonia (Institut d'Investigació Biomèdica Sant Pau)
Llauger, Jaume (Institut d'Investigació Biomèdica Sant Pau)
Diaz-Manera, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Quantitative MRI is an increasingly used method to monitor disease progression in muscular disorders due to its ability to measure changes in muscle fat content (reported as fat fraction) over a short period. Being able to objectively measure such changes is crucial for the development of new treatments in clinical trials. However, the analysis of the images involved continues to be a daunting task because of the time needed. Whether a more specific analysis selecting individual muscles or a global one analyzing the whole thigh or compartments could be a suitable alternative has only been marginally studied. In our study we compare three methods of analysis of 2-point-dixon images in a cohort of 34 patients with late onset Pompe disease followed over a period of one year. We measured fat fraction on MRIs obtained at baseline and at year 1, and we calculated the increment of fat fraction. We correlated the results obtained with the results of muscle function tests to investigate whether the three methods of analysis were equivalent or not. We observed significant differences between the three methods in the estimation of the fat fraction at both baseline and year 1, but no difference was found in the increment in fat fraction between baseline and year 1. When we correlated the fat fraction obtained with each method and the muscle function tests, we found a significant correlation with most tests in all three methods, although in most comparisons the highest correlation coefficient was found with the analysis of individual muscles. We conclude that the fastest strategy of analysis assessing compartments or the whole thigh could be reliable for certain cohorts of patients where the variable to study is the fat increment. In other sorts of studies, an individual muscle approach seems the most reliable technique.
Ajuts:	Instituto de Salud Carlos III Fondos FEDER-ISCIII PI18/1525
Nota:	Altres ajuts: Asociación Española de Enfermos de Glucogenosis (AEEG)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Quantitative MRI ; Dixon ; Pompe ; Fat replacement ; Outcome measures
Publicat a:	Frontiers in neurology, Vol. 12 (august 2021) , p. 675781, ISSN 1664-2295

DOI: 10.3389/fneur.2021.675781
PMID: 34305788

8 p, 1.1 MB

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