Host-driven subspeciation in the hedgehog fungus, Trichophyton erinacei, an emerging cause of human dermatophytosis
Čmoková, A. (Charles University. Academy of Sciences of the Czech Republic)
Kolařík, M. (Academy of Sciences of the Czech Republic)
Guillot, J. (École nationale vétérinaire d'Alfort.)
Risco-Castillo, V. (École nationale vétérinaire d'Alfort)
Cabañes Sáenz, Francisco Javier (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)
Nenoff, P. (Laboratory of Medical Microbiology)
Uhrlaß, S. (Laboratory of Medical Microbiology)
Dobiáš, R. (Public Health Institute in Ostrava. University of Ostrava)
Mallátová, N. (Hospital České Budě-jovice)
Yaguchi, T. (Chiba University)
Kano, R. (Teikyo University)
Kuklová, I. (Charles University)
Lysková, P. (Laboratory of Mycology)
Mencl, K. (Pardubice Regional Hospital)
Hamal, P. (Palacký University Olomouc)
Peano, A. (Università degli Studi di Torino)
Hubka, V. (Universitat Autònoma de Barcelona. Departament de Sanitat i d'Anatomia Animals)

Data:	2022
Descripció:	6 pàg.
Resum:	Trichophyton erinacei is a main cause of dermatophytosis in hedgehogs and is increasingly reported from human infections worldwide. This pathogen was originally described in the European hedgehog (Erinaceus europaeus) but is also frequently found in the African four-toed hedgehog (Atelerix albiventris), a popular pet animal worldwide. Little is known about the taxonomy and population genetics of this pathogen despite its increasing importance in clinical practice. Notably, whether there are different populations or even cryptic species associated with different hosts or geographic regions is not known. To answer these questions, we collected 161 isolates, performed phylogenetic and population-genetic analyses, determined mating-type, and characterised morphology and physiology. Multigene phylogeny and microsatellite analysis supported T. erinacei as a monophyletic species, in contrast to highly incongruent single-gene phylogenies. Two main subpopulations, one specific mainly to Atelerix and second to Erinaceus hosts, were identified inside T. erinacei, and slight differences in the size of microconidia and antifungal susceptibilities were observed among them. Although the process of speciation into two lineages is ongoing in T. erinacei, there is still gene flow between these populations. Thus, we present T. erinacei as a single species, with notable intraspecies variability in genotype and phenotype. The data from wild hedgehogs indicated that sexual reproduction in T. erinacei and de novo infection of hedgehogs from soil are probably rare events and that clonal horizontal spread strongly dominates. The molecular typing approach used in this study represents a suitable tool for further epidemiological surveillance of this emerging pathogen in both animals and humans. The results of this study also highlighted the need to use a multigene phylogeny ideally in combination with other inde-pendent molecular markers to understand the species boundaries of dermatophytes.
Nota:	Altres ajuts: Czech Ministry of Health (grant NU21-05-00681)
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Epizootic fungal infections ; Microsatellite typing ; Multigene phylogeny ; Population genetics ; Skin infections ; Trichophyton benhamiae complex ; Zoophilic dermatophytes
Publicat a:	Persoonia: Molecular Phylogeny and Evolution of Fungi, Vol. 48 (2022) , p. 203-208, ISSN 0031-5850

DOI: 10.3767/persoonia.2022.48.06
DOI: 10.3767/persoonia.2023.48.06
PMID: 38234687

16 p, 2.2 MB

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