One year of omega 3 polyunsaturated fatty acid supplementation does not reduce circulating prothrombotic microvesicles in elderly subjects after suffering a myocardial infarction
Chiva-Blanch, Gemma (University of Oslo. Faculty of Medicine)
Bratseth, Vibeke (Faculty of Medicine. University of Oslo)
Laake, Kristian (Faculty of Medicine. University of Oslo)
Arnesen, Harald (Faculty of Medicine. University of Oslo)
Solheim, Svein (Faculty of Medicine. University of Oslo)
Schmidt, Erik Berg (Aalborg University Hospital (Dinamarca))
Badimon, Lina (Institut d'Investigació Biomèdica Sant Pau)
Seljeflot, Ingebjørg (Faculty of Medicine. University of Oslo)

Data:	2021
Resum:	Background & aims: Circulating microvesicles (cMV) are both effectors and biomarkers of cardiovascular disease (CVD), and the effects of omega 3 polyunsaturated fatty acids (n3 PUFA) in MV shedding are not yet well known. Therefore, we aimed to investigate the effects of long-term n3 PUFA supplementation on cMV release from cells of the vascular compartment in elderly subjects at very high risk of CVD. Methods: We included 156 elderly patients 2-8 weeks after suffering an acute myocardial infarction from the OMEMI cohort. Subjects were randomly allocated to receive 930 mg EPA + 660 mg DHA (n3 PUFA intervention) or corn oil (56% linoleic acid, 32% oleic acid, 10% palmitic acid) used as placebo daily for two years. At inclusion and after one-year follow-up, prothrombotic [annexin V (AV)] cMV derived from blood and vascular cells were phenotyped by flow cytometry. Results: No differences were observed in the levels of cMV between the randomized groups at inclusion in the study. After one-year follow-up, total AV, platelet-derived CD61/AV, and endothelial-derived CD31/AV and CD31/CD42b/AV cMV increased significantly in both groups. In the n3 PUFA supplemented group, platelet-derived CD62P/AV, CD42b/AV and CD31/CD42b/AV; leukocyte-derived CD62L/AV, CD45/AV, and CD11b/AV, as well as endothelial derived CD146/AV, CD62E/AV, and CD309/AV cMV also increased significantly. No significant differences were however, observed in the changes of cMV levels between groups. Conclusion: In elderly Norwegians who have suffered a recent acute myocardial infarction and treated as per guidelines, long-term supplementation with 1. 8 g/day n3 PUFA does not modulate prothrombotic MV release from blood and vascular cells. Registration: URL: https://www. clinicaltrials. gov; Unique identifier: NCT01841944.
Nota:	Altres ajuts: Stein Erik Hagens Foundation of Clinical Heart Research, Oslo, Norway.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Microvesicles ; Omega 3 fatty acids ; EPA ; DHA ; Elderly ; Thrombosis
Publicat a:	Clinical Nutrition (Edinburgh, Scotland), Vol. 40 Núm. 12 (december 2021) , p. 5674-5677, ISSN 1532-1983

DOI: 10.1016/j.clnu.2021.10.007
PMID: 34742136

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