Sarcoma classification by DNA methylation profiling
Koelsche, Christian (Heidelberg University Hospital (Alemanya))
Schrimpf, Daniel (German Cancer Research Center)
Stichel, Damian (German Cancer Research Center)
Sill, Martin (German Cancer Research Center)
Sahm, Felix (German Cancer Research Center)
Reuss, David E. (German Cancer Research Center)
Blattner, Mirjam (German Cancer Research Center)
Worst, Barbara (Heidelberg University Hospital (Alemanya))
Heilig, Christoph E. (German Cancer Consortium)
Beck, Katja (German Cancer Research Center)
Horak, Peter (German Cancer Consortium)
Kreutzfeldt, Simon (German Cancer Consortium)
Paff, Elke (Heidelberg University Hospital (Alemanya))
Stark, Sebastian (Heidelberg University Hospital (Alemanya))
Johann, Pascal (Heidelberg University Hospital (Alemanya))
Selt, Florian (German Cancer Research Center)
Ecker, Jonas (German Cancer Research Center)
Sturm, Dominik (Heidelberg University Hospital (Alemanya))
Pajtler, Kristian W. (Heidelberg University Hospital (Alemanya))
Reinhardt, Annekathrin (German Cancer Research Center)
Wefers, Annika K. (German Cancer Research Center)
Sievers, Philipp (German Cancer Research Center)
Ebrahimi, Azadeh (German Cancer Research Center)
Suwala, Abigail (German Cancer Research Center)
Fernández-Klett, Francisco (German Cancer Research Center)
Casalini, Belén (German Cancer Research Center)
Korshunov, Andrey (German Cancer Research Center)
Hovestadt, Volker (Harvard Medical School)
Kommoss, Felix K.F. (DHeidelberg University Hospital)
Kriegsmann, Mark (Heidelberg University Hospital (Alemanya))
Schick, Matthias (German Cancer Research Center)
Bewerunge-Hudler, Melanie (German Cancer Research Center)
Milde, Till (German Cancer Research Center)
Witt, Olaf (German Cancer Research Center)
Kulozik, Andreas E. (eidelberg University Hospital)
Kool, Marcel (German Cancer Research Center)
Romero-Pérez, Laura (LMU Munich)
Grünewald, Thomas G.P. (LMU Munich)
Kirchner, Thomas (LMU Munich)
Wick, Wolfgang (German Cancer Research Center)
Platten, Michael (German Cancer Research Center)
Unterberg, Andreas (Heidelberg University Hospital (Alemanya))
Uhl, Matthias (Heidelberg Institute of Radiation Oncology)
Abdollahi, Amir (German Cancer Research Center)
Debus, Jürgen (German Cancer Research Center)
Lehner, Burkhard (Heidelberg University Hospital (Alemanya))
Thomas, Christian (University Hospital of Münster (Alemanya))
Hasselblatt, Martin (University Hospital of Münster (Alemanya))
Paulus, Werner (University Hospital of Münster (Alemanya))
Hartmann, Christian (Hannover Medical School)
Staszewski, Ori (University of Freiburg)
Prinz, Marco (University of Freiburg)
Hench, Jürgen (University Hospital Basel (Basilea, Suïssa))
Frank, Stephan (University Hospital Basel (Basilea, Suïssa))
Versleijen-Jonkers, Yvonne M.H. (Radboud University Medical Center)
Weidema, Marije E. (Radboud University Medical Center)
Mentzel, Thomas (Dermatopathology Bodensee)
Griewank, Klaus (University Duisburg-Essen)
De Álava, Enrique (Universidad de Sevilla)
Díaz-Martín, Juan (Instituto de Biomedicina de Sevilla)
Idoate Gastearena, Miguel A. (Clínica Universidad de Navarra)
Chang, Kenneth Tou-En (Department of Pathology and Laboratory Medicine. KK Women's and Children's Hospital)
Low, Sharon Yin Yee (National Neuroscience Institute (Singapur))
Cuevas-Bourdier, Adrian (Laboratoire National de Santé (França))
Mittelbronn, Michel (Luxembourg Institute of Health)
Mynarek, Martin (University Medical Center Hamburg-Eppendorf)
Rutkowski, Stefan (University Medical Center Hamburg-Eppendorf)
Schüller, Ulrich (Research Institute Children's Cancer Center Hamburg)
Mautner, Viktor F. (University Medical Center Hamburg-Eppendorf)
Schittenhelm, Jens (Institute of Pathology and Neuropathology. University Hospital of Tübingen)
Serrano, Jonathan (New York University School of Medicine)
Snuderl, Matija (New York University School of Medicine)
Büttner, Reinhard (Uniklinik Köln (Colònia, Alemanya))
Klingebiel, Thomas (University Children's Hospital)
Buslei, Rolf (Sozialstiftung Bamberg. Klinikum am Bruderwald)
Gessler, Manfred (Würzburg University)
Wesseling, Pieter (Amsterdam University Medical Centers/VUmc)
Dinjens, Winand N.M. (Erasmus MC Cancer Institute)
Brandner, Sebastian (University College London Hospitals NHS Foundation Trust)
Jaunmuktane, Zane (University College London)
Lyskjær, Iben (University College London)
Schirmacher, Peter (Heidelberg University Hospital (Alemanya))
Stenzinger, Albretch (Heidelberg University Hospital (Alemanya))
Brors, Benedikt (German Cancer Research Center)
Glimm, Hanno (German Cancer Consortium)
Heining, Christoph (German Cancer Consortium)
Tirado, Oscar M. (Institut d'Investigació Biomèdica de Bellvitge)
Sáinz-Jaspeado, Miguel (Institut d'Investigació Biomèdica de Bellvitge)
Mora, Jaume (Hospital Sant Joan de Déu (Barcelona, Catalunya))
Alonso, Javier (Instituto de Salud Carlos III)
Garcia del Muro, Xavier (Institut d'Investigació Biomèdica de Bellvitge)
Moran, S (Institut d'Investigació Biomèdica de Bellvitge)
Esteller, M (Institut Germans Trias i Pujol. Institut de Recerca contra la Leucèmia Josep Carreras)
Benhamida, Jamal K. (Memorial Sloan Kettering Cancer Center)
Ladanyi, Marc (Department of Pathology. Memorial Sloan Kettering Cancer Center)
Wardelmann, Eva (University Hospital of Münster (Alemanya))
Antonescu, Cristina (Memorial Sloan Kettering Cancer Center)
Flanagan, Adrienne (University College London Cancer Institute)
Dirksen, Uta (University Duisburg-Essen)
Hohenberger, Peter (University of Heidelberg)
Baumhoer, Daniel (University Hospital Basel (Basilea, Suïssa))
Hartmann, Wolfgang (University Hospital of Münster (Alemanya))
Vokuhl, Christian (Universitätsklinikum Schleswig-Holstein (Alemanya))
Flucke, Uta (Radboud University Medical Center)
Petersen, Iver (Institute of Pathology)
Mechtersheimer, Gunhild (Heidelberg University Hospital (Alemanya))
Capper, David (Charité - Universitätsmedizin Berlin)
Jones, David T.W. (PGerman Cancer Research Center)
Fröhling, Stefan (German Cancer Consortium)
Pfister, Stefan M. (Heidelberg University Hospital (Alemanya))
von Deimling, Andreas (German Cancer Research Center)

Data:	2021
Resum:	Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features. Therefore, the diagnosis of sarcomas is burdened with a high inter-observer variability and misclassification rate. Here, we demonstrate classification of soft tissue and bone tumours using a machine learning classifier algorithm based on array-generated DNA methylation data. This sarcoma classifier is trained using a dataset of 1077 methylation profiles from comprehensively pre-characterized cases comprising 62 tumour methylation classes constituting a broad range of soft tissue and bone sarcoma subtypes across the entire age spectrum. The performance is validated in a cohort of 428 sarcomatous tumours, of which 322 cases were classified by the sarcoma classifier. Our results demonstrate the potential of the DNA methylation-based sarcoma classification for research and future diagnostic applications.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Algorithms ; Bone Neoplasms ; Cohort Studies ; DNA Copy Number Variations ; DNA Methylation ; Humans ; Internet ; Machine Learning ; Reproducibility of Results ; Sarcoma ; Sensitivity and Specificity ; Soft Tissue Neoplasms
Publicat a:	Nature communications, Vol. 12 Núm. 1 (january 2021) , p. 498, ISSN 2041-1723

DOI: 10.1038/s41467-020-20603-4
PMID: 33479225

10 p, 2.4 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP) > Institut de Recerca contra la Leucèmia Josep Carreras
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