Impact of the -2 pandemic on the health of individuals with intoxication-type metabolic diseases-Data from the consortium
Mütze, Ulrike (Heidelberg University Hospital (Alemanya))
Gleich, Florian (Heidelberg University Hospital (Alemanya))
Barić, Ivo (University Hospital Center Zagreb)
Baumgartner, Mathias (University Children's Hospital and Children's Research Center)
Burlina, Alberto (University Hospital Padova)
Chapman, Kimberly A. (Children's National Medical Center)
Chien, Yin-Hsiu (National Taiwan University Hospital (Taiwan))
Cortès-Saladelafont, Elisenda (Universitat Autònoma de Barcelona)
De Laet, Corinne (Hôpital Universitaire des Enfants Reine Fabiola-Université Libre de Bruxelles)
Dobbelaere, Dries (Jeanne de Flandre University Hospital and RADEME Research Team for Rare Metabolic and Developmental Diseases)
Eysken, Francois (University Hospital of Antwerp UZA)
Gautschi, Matthias (University Hospital Bern)
Santer, Rene (University Children's Hospital, University Medical Centre Hamburg-Eppendorf)
Häberle, Johannes (University Children's Hospital and Children's Research Center, University of Zurich)
Joaquín, Clara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Karall, Daniela (Medical University of Innsbruck)
Lindner, Martin (Goethe University Frankfurt/Main, Uni.-Children's Hospital)
Lund, Allan M. (Copenhagen University Hospital)
Mühlhausen, Chris (Universitätsmedizin Göttingen)
Murphy, Elaine (National Hospital for Neurology and Neurosurgery)
Roland, Dominique (Institute of Pathology and Human Genetics (Bèlgica))
Ruiz Gomez, Angeles (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Skouma, Anastasia (Institouto Ygeias Tou Paidiou (Grècia))
Grünert, Sarah C. (University of Freiburg)
Wagenmakers, Margreet (Erasmus Medical Center)
Garbade, Sven F. (Heidelberg University Hospital (Alemanya))
Kölker, Stefan (Heidelberg University Hospital (Alemanya))
Boy, Nikolas (Heidelberg University Hospital (Alemanya))

Date:	2022
Abstract:	The SARS-CoV-2 pandemic challenges healthcare systems worldwide. Within inherited metabolic disorders (IMDs) the vulnerable subgroup of intoxication-type IMDs such as organic acidurias (OA) and urea cycle disorders (UCD) show risk for infection-induced morbidity and mortality. This study (observation period February 2020 to December 2021) evaluates impact on medical health care as well as disease course and outcome of SARS-CoV-2 infections in patients with intoxication-type IMDs managed by participants of the European Registry and Network for intoxication type metabolic diseases Consortium (E-IMD). Survey's respondents managing 792 patients (n = 479 pediatric; n = 313 adult) with intoxication-type IMDs (n = 454 OA; n = 338 UCD) in 14 countries reported on 59 (OA: n = 36; UCD: n = 23), SARS-CoV-2 infections (7. 4%). Medical services were increasingly requested (95%), mostly alleviated by remote technologies (86%). Problems with medical supply were scarce (5%). Regular follow-up visits were reduced in 41% (range 10%-50%). Most infected individuals (49/59; 83%) showed mild clinical symptoms, while 10 patients (17%; n = 6 OA including four transplanted MMA patients; n = 4 UCD) were hospitalized (metabolic decompensation in 30%). ICU treatment was not reported. Hospitalization rate did not differ for diagnosis or age group (p = 0. 778). Survival rate was 100%. Full recovery was reported for 100% in outpatient care and 90% of hospitalized individuals. SARS-CoV-2 impacts health care of individuals with intoxication-type IMDs worldwide. Most infected individuals, however, showed mild symptoms and did not require hospitalization. SARS-CoV-2-induced metabolic decompensations were usually mild without increased risk for ICU treatment. Overall prognosis of infected individuals is very promising and IMD-specific or COVID-19-related complications have not been observed.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coronavirus ; COVID-19 ; E-IMD ; IMD ; Intoxication-type inherited metabolic diseases ; Pandemic ; SARS-CoV-2 ; Survey
Published in:	Journal of Inherited Metabolic Disease, november 2022, ISSN 1573-2665

DOI: 10.1002/jimd.12572
PMID: 36266255

12 p, 2.6 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Articles > Research articles
Articles > Published articles