Differences in nutritional status and inflammatory biomarkers between female and male patients with bronchiectasis : A large-cohort study
Wang, Xuejie (Universitat Autònoma de Barcelona. Departament de Medicina)
Villa, Carmen (Clínica Fuensanta)
Dobarganes, Yadira (Clínica Fuensanta)
Olveira, Casilda (Instituto de Investigación Biomédica de Málaga (IBIMA). Universidad de Málaga)
Girón, Rosa (Instituto de Investigación Hospital Universitario de la Princesa)
García-Clemente, Marta (Hospital Universitario Central de Asturias)
Maíz, Luis (Hospital Universitario Ramón y Cajal (Madrid))
Sibila, Oriol (Centro de Investigación Biomédica en Red de Enfermedades Respiratorias)
Golpe, Rafael (Hospital Universitario Lucus Augusti (Lugo))
Menéndez, Rosario (Hospital Universitari i Politècnic La Fe (València))
Rodríguez-López, Juan (Hospital Universitario San Agustín (Avilés))
Prados, Concepción (Hospital Universitario La Paz (Madrid))
Martínez-García, Miguel Ángel (Hospital Universitari i Politècnic La Fe (València))
Rodriguez Hermosa, Juan Luis (Universidad Complutense de Madrid. Departamento de Medicina)
de la Rosa Carrillo, David (Institut d'Investigació Biomèdica Sant Pau)
Duran-Jordà, Xavier (Institut Hospital del Mar d'Investigacions Mèdiques)
Barreiro, Esther (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Universitat Autònoma de Barcelona

Date:	2021
Abstract:	We hypothesized that systemic inflammatory and nutritional parameters may differ between male and female patients with non-CF bronchiectasis. In a large patient cohort from the Spanish Online Bronchiectasis Registry (RIBRON), clinical features, systemic inflammatory and nutritional parameters were analyzed in male and female patients with bronchiectasis. Lung func-tion, disease severity using several scores, nutritional status, systemic inflammatory parameters, and multivariate regression analyses were performed to identify differences between male and female patients in the target variables. The number of female patients included in the registry was greater than male patients and they had a less severe disease as measured by all three indices of disease severity, a lower degree of airway obstruction, worse diffusion capacity and airway trapping, better nutritional parameters, and lower levels of inflammatory biomarkers. Multivariate regression analysis evidenced that strong relationships were found between female gender and the following variables: total numbers of leukocytes and neutrophils, hemoglobin, hematocrit, creatinine, and body mass index (BMI). Multivariate regression analyses evidenced that nutritional parameters and inflammatory biomarkers may be reliable indicators of gender-related differences in patients with non-CF bronchiectasis. These findings deserve further attention in follow-up investigations in which the potential predictive value of those biomarkers should be thoroughly explored.
Grants:	Instituto de Salud Carlos III FIS 18/00075 Instituto de Salud Carlos III FIS 21/00215
Note:	Altres ajuts: Fondo Europeo de Desarrollo Regional (FEDER); CIBERES (ISC-III); SEPAR 2020; ZAMBON-PHARMA (Spain).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Bronchiectasis ; Gender-related differences ; Systemic inflammation ; Nutritional status ; Biomarkers ; Disease severity
Published in:	Biomedicines, Vol. 9 Núm. 8 (august 2021) , p. 905, ISSN 2227-9059

DOI: 10.3390/biomedicines9080905
PMID: 34440109

17 p, 2.6 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles