The efficacy and tolerability of tetracyclines and clindamycin plus rifampicin for the treatment of hidradenitis suppurativa : Results of a prospective European cohort study
van Straalen, Kelsey R. (Erasmus MC. University Medical Center Rotterdam. Department of Dermatology)
Tzellos, Thrasyvoulos (Department of Dermatology. Nordland Hospital Trust)
Guillem, Phillipe (Groupe de Recherche en Proctologie de la Société Nationale Française de ColoProctologie)
Benhadou, Farida (Department of Dermatology. Université Libre de Bruxelles. Erasme Hospital)
Cuenca-Barrales, Carlos (TECe19-Clinical and Translational Dermatology Investigation Group Instituto de Investigación Biosanitaria)
Daxhelet, Mathilde (Department of Dermatology. Université Libre de Bruxelles. Erasme Hospital)
Daoud, Mathieu (Department of Dermatology. Université Libre de Bruxelles. Erasme Hospital)
Efthymiou, Ourania (Attikon University General Hospital)
Giamarellos-Bourboulis, Evangelos J. (Fourth Department of Internal Medicine. National and Kapodistrian University of Athens. Medical School)
Jemec, Gregor B.E. (Department of Dermatology. Zealand University Hospital. Roskilde and Health Sciences Faculty. University of Copenhagen)
Katoulis, Alexandros C. (Attikon University General Hospital)
Koenig, Anke (Department of Dermatology. Venereology and Allergology. University Hospital Frankfurt am Main)
Lazaridou, Elizabeth (George Papanicolaou General Hospital (Tessalònica, Grècia))
Marzano, Angelo V. (Department of Pathophysiology and Transplantation. Università degli Studi di Milano)
Matusiak, Łucas (Department of Dermatology. Venereology and Allergology. Medical University)
Molina-Leyva, Alejandro (TECe19-Clinical and Translational Dermatology Investigation Group Instituto de Investigación Biosanitaria)
Moltrasio, Chiara (Department of Medical Surgical and Health Sciences. University of Trieste)
Pinter, Andreas (Department of Dermatology. Venereology and Allergology. University Hospital Frankfurt am Main)
Potenza, Concetta (Dermatology Unit 'Daniele Innocenzi. ' Department of Medical-Surgical Sciences and Biotechnologies. Sapienza University of Rome)
Romaní, Jorge (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Saunte, Ditte M. (Department of Dermatology. Zealand University Hospital. Roskilde and Health Sciences Faculty. University of Copenhagen)
Skroza, Nevena (Dermatology Unit 'Daniele Innocenzi. ' Department of Medical-Surgical Sciences and Biotechnologies. Sapienza University of Rome)
Stergianou, Dimitra (Fourth Department of Internal Medicine. National and Kapodistrian University of Athens. Medical School)
Szepietowski, Jacek (Department of Dermatology. Venereology and Allergology. Medical University)
Trigoni, Anastasia (George Papanicolaou General Hospital (Tessalònica, Grècia))
Vilarrasa-Rull, Eva (Institut d'Investigació Biomèdica Sant Pau)
van der Zee, Hessel H. (Erasmus MC. University Medical Center Rotterdam. Department of Dermatology)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	Background: Tetracyclines and clindamycin plus rifampicin combination therapy are both considered first-line therapy in current hidradenitis suppurativa guidelines. However, evidence for their efficacy is drawn from small studies, often without validated outcomes. Objective: To assess the 12-week efficacy of oral tetracyclines and a combination of clindamycin and rifampicin. Methods: A prospective, international cohort study performed between October 2018 and August 2019. Results: In total, 63. 6% of the included 283 patients received oral tetracyclines, and 36. 4% were treated with clindamycin and rifampicin. Both groups showed a significant decrease in International Hidradenitis Suppurativa Severity Score System from baseline (both P <. 001). The Hidradenitis Suppurativa Clinical Response (HiSCR) was achieved in 40. 1% and 48. 2% of patients, respectively (P =. 26). Patient characteristics or disease severity were not associated with the attainment of HiSCR or the minimal clinically important differences for the Dermatology Life Quality Index and pain. Limitations: Cohort study. Respectively, 23. 9% and 19. 4% of patients had to be excluded from the HiSCR analysis for the tetracycline and combination therapy group because of a low abscess and nodule count at baseline. Conclusion: This study shows significant efficacy of both tetracycline treatment and clindamycin and rifampicin combination therapy after 12 weeks in patients with hidradenitis suppurativa. No significant differences in efficacy were observed between the 2 treatments, regardless of disease severity.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acne inversa ; Antibiotics ; Clindamycin ; Doxycycline ; Efficacy ; Guideline ; Minocycline ; Outcome ; Rifampicin ; Tetracycline ; Therapy ; Treatment
Publicat a:	Journal of the American Academy of Dermatology, Vol. 85 Núm. 2 (august 2021) , p. 369-378, ISSN 1097-6787

DOI: 10.1016/j.jaad.2020.12.089
PMID: 33484766

10 p, 390.5 KB

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