DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death
Bonassi, Stefano (San Raffaele University)
Ceppi, Marcello (San Martino Policlinic Hospital)
Møller, Peter (University of Copenhagen)
Azqueta, Amaya (Universidad de Navarra)
Milić, Mirta (Institute for Medical Research and Occupational Health)
Neri, Monica (IRCCS San Raffaele Roma)
Brunborg, Gunnar (Norwegian Institute of Public Health)
Godschalk, Roger (University of Maastricht. Department of Pharmacology and Toxicology)
Koppen, Gudrun (Flemish Institute of Technological Research)
Langie, Sabine (University of Maastricht. Department of Pharmacology and Toxicology)
Teixeira, João Paulo (Instituto de Saúde Pública, Universidade Do Porto)
Bruzzone, Marco (San Martino Policlinic Hospital)
Da Silva, Juliana (Lutheran University of Brazil)
Benedetti, Danieli (Lutheran University of Brazil)
Cavallo, Delia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene)
Ursini, Cinzia Lucia (Department of Occupational and Environmental Medicine, Epidemiology and Hygiene)
Giovannelli, Lisa (University of Florence. Department NEUROFARBA)
Moretti, Silvia (University of Florence. Department of Health Sciences)
Riso, Patrizia (University of Milan. Department of Food, Environmental and Nutritional Sciences)
Del Bo', Cristian (University of Milan. Department of Food, Environmental and Nutritional Sciences)
Russo, Patrizia (San Raffaele University)
Dobrzyńska, Malgorzata (National Institute of Public Health NIH)
Goroshinskaya, Irina A. (National Medical Research Center for Oncology)
Surikova, Ekaterina I. (National Medical Research Center for Oncology)
Staruchova, Marta (Slovak Medical University)
Barančoková, Magdalena (Slovak Medical University)
Volkovova, Katarina (Slovak Medical University)
Kažimirova, Alena (Slovak Medical University)
Smolkova, Bozena (Slovak Academy of Sciences)
Laffon, Blanca (Instituto de Investigación Biomédica de A Coruña)
Valdiglesias, Vanessa (Universidade da Coruña)
Pastor Benito, Susana (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Marcos Dauder, Ricardo (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Hernández Bonilla, Alba (Universitat Autònoma de Barcelona. Departament de Genètica i de Microbiologia)
Gajski, Goran (Institute for Medical Research and Occupational Health)
Spremo-Potparević, Biljana (University of Belgrade)
Živković, Lada (University of Belgrade)
Boutet-Robinet, Elisa (Université de Toulouse)
Perdry, Hervé (Univ Paris-Saclay)
Lebailly, Pierre (Centre François Baclesse (Caen, França))
Perez, Carlos L. (Universidad de Ciencias Médicas de La Habana)
Basaran, Nursen (Hacettepe University. Department of Pharmaceutical Toxicology)
Nemeth, Zsuzsanna (National Public Health Center)
Safar, Anna (National Public Health Center)
Dusinska, Maria (Health Effects Laboratory)
Collins, Andrew R (University of Oslo. Department of Nutrition)

Date:	2021
Abstract:	The comet assay or single cell gel electrophoresis, is the most common method used to measure strand breaks and a variety of other DNA lesions in human populations. To estimate the risk of overall mortality, mortality by cause, and cancer incidence associated to DNA damage, a cohort of 2,403 healthy individuals (25,978 person-years) screened in 16 laboratories using the comet assay between 1996 and 2016 was followed-up. Kaplan-Meier analysis indicated a worse overall survival in the medium and high tertile of DNA damage (p < 0. 001). The effect of DNA damage on survival was modelled according to Cox proportional hazard regression model. The adjusted hazard ratio (HR) was 1. 42 (1. 06-1. 90) for overall mortality, and 1. 94 (1. 04-3. 59) for diseases of the circulatory system in subjects with the highest tertile of DNA damage. The findings of this study provide epidemiological evidence encouraging the implementation of the comet assay in preventive strategies for non-communicable diseases.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Biomarkers ; Risk factors
Published in:	Scientific reports, Vol. 11 (August 2021) , art. 16793, ISSN 2045-2322
Related work:	Bonassi, Stefano; Ceppi, Marcello ; Møller, Peter ; [et al.]. «Author Correction : DNA damage in circulating leukocytes measured with the comet assay may predict the risk of death». Scientific reports, Vol. 11 (September 2021), art. 19043 https://doi.org/10.1038/s41598-021-98620-6

Correcció de l'article: https://ddd.uab.cat/record/273301
DOI: 10.1038/s41598-021-95976-7
PMID: 34408182

11 p, 1.1 MB

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