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| Home > Articles > Published articles > Efficient tumor eradication at ultralow drug concentration via externally controlled and boosted metallic iron magnetoplasmonic nanocapsules |
(The Hebrew University of Jerusalem. Institute for Drug Research) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (Universitat Autònoma de Barcelona. Departament de Física) (Universitat Autònoma de Barcelona) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (Institut Català de Nanociència i Nanotecnologia) (The Hebrew University of Jerusalem. Institute for Drug Research) (Institut de Microelectrònica de Barcelona)
| Date: | 2023 |
| Abstract: | With the aim to locally enhance the efficacy of cancer nanotherapies, here we present metal iron based magnetoplasmonic drug-loaded nanocapsules (MAPSULES), merging powerful external magnetic concentration in the tumor and efficient photothermal actuation to locally boost the drug therapeutic action at ultralow drug concentrations. The MAPSULES are composed of paclitaxel-loaded polylactic-co-glycolic acid (PLGA) nanoparticles partially coated by a nanodome shape iron/silica semishell. The iron semishell has been designed to present a ferromagnetic vortex for incorporating a large quantity of ferromagnetic material while maintaining high colloidal stability. The large iron semishell provides very strong magnetic manipulation via magnetophoretic forces, enabling over 10-fold higher trapping efficiency in microfluidic channels than typical superparamagnetic iron oxide nanoparticles. Moreover, the iron semishell exhibits highly damped plasmonic behavior, yielding intense broadband absorbance in the near-infrared biological windows and photothermal efficiency similar to the best plasmonic nanoheaters. The in vivo therapeutic assays in a mouse xenograft tumor model show a high amplification of the therapeutic effects by combining magnetic concentration and photothermal actuation in the tumor, leading to a complete eradication of the tumors at ultralow nanoparticle and drug concentration (equivalent to only 1 mg/kg PLGA nanoparticles containing 8 μg/kg of paclitaxel, i. e. , 100-500-fold lower than the therapeutic window of the free and PLGA encapsulated drug and 13-3000-fold lower than current nanotherapies combining paclitaxel and light actuation). These results highlight the strength of this externally controlled and amplified therapeutic approach, which could be applied to locally boost a wide variety of drugs for different diseases. |
| Grants: | Agencia Estatal de Investigación MAT2016-77391-R Agencia Estatal de Investigación PID2019-106229RB-I00 Agencia Estatal de Investigación PID2020-116844RB-C21 Agencia Estatal de Investigación PGC2018-095032-B-100 Agencia Estatal de Investigación PCIN2016-093 Agencia Estatal de Investigación RTI2018-095495-J-I00 Agencia Estatal de Investigación RYC2019-027449-I Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-292 Agencia Estatal de Investigación SEV-2017-0706 |
| Note: | Altres ajuts: ERC proof of concept grant (ERC-2022-PoC1), Ramon Areces foundation through grant CIVP19A5922 and CERCA programme/Generalitat de Catalunya. |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Subject: | Nanocapsules ; Photothermal therapy ; Magnetic manipulation ; Paclitaxel ; Breast cancer |
| Published in: | ACS nano, Vol. 17, Issue 3 (February 2023) , p. 1946-1958, ISSN 1936-086X |
