Quantifying the patient's perspective in neuromyelitis optica spectrum disorder : Psychometric properties of the SymptoMScreen questionnaire
Meca-Lallana, J.E. (Instituto Murciano de Investigación Biosanitaria)
Maurino, J. (Medical Department)
Pérez-Miralles, F. (Hospital Universitari i Politècnic La Fe (València))
Forero, L. (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Sepúlveda, M. (Hospital Clínic i Provincial de Barcelona)
Calles, Carmen (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Martínez-Ginés, M.L. (Hospital General Universitario Gregorio Marañón)
González-Suárez, I. (Hospital Álvaro Cunqueiro (Vigo))
Boyero, Sabas (Hospital Universitario de Cruces (Barakaldo, País Basc))
Romero-Pinel, L. (Hospital Universitari de Bellvitge)
Sempere, Á.P. (Hospital General Universitario de Alicante (Alacant, País Valencià))
Meca-Lallana, Virginia (Hospital Universitario de la Princesa (Madrid))
Querol, Luis (Institut d'Investigació Biomèdica Sant Pau)
Costa-Frossard, Lucienne (Hospital Universitario Ramón y Cajal (Madrid))
Prefasi, D. (Medical Department)
Gómez-Ballesteros, Rocío (Medical Department. Roche Farma)
Ballesteros, J. (Instituto de Investigación Sanitaria Biocruces Bizkaia)

Data:	2021
Resum:	Background The assessment of self-reported outcomes in neuromyelitis optica spectrum disorder (NMOSD) is limited by the lack of validated disease-specific measures. The SymptoMScreen (SyMS) is a patient-reported questionnaire for measuring symptom severity in different domains affected by multiple sclerosis (MS), but has not been thoroughly evaluated in NMOSD. The aim of this study was to assess the psychometric properties of the SyMS in a sample of patients with NMOSD. Methods A non-interventional, cross-sectional study in adult subjects with NMOSD (Wingerchuk 2015 criteria) was conducted at 13 neuroimmunology clinics applying the SyMS. A nonparametric item response theory procedure, Mokken analysis, was performed to assess the underlying dimensional structure and scalability of items and overall questionnaire. All analyses were performed with R (v4. 0. 3) using the mokken library. Results A total of 70 patients were studied (mean age: 47. 5 ± 15 years, 80% female, mean Expanded Disability Status Scale score: 3. 0 [interquartile range 1. 5, 4. 5]). Symptom severity was low (median SyMS score: 19. 0 [interquartile range 10. 0, 32. 0]). The SyMS showed a robust internal reliability (Cronbach's alpha: 0. 90 [95% confidence interval 0. 86, 0. 93]) and behaved as a unidimensional scale with all items showing scalability coefficients > 0. 30. The overall SyMS scalability was 0. 45 conforming to a medium scale according to Mokken's criteria. Fatigue and body pain were the domains with the highest scalability coefficients. The SyMS was associated with disability (rho: 0. 586), and physical and psychological quality of life (rho: 0. 856 and 0. 696, respectively). Conclusions The SyMS shows appropriate psychometric characteristics and may constitute a valuable and easy-to-implement option to measure symptom severity in patients with NMOSD.
Nota:	Altres ajuts: Medical Department of Roche Farma Spain (ML41397).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Neuromyelitis Optica ; Psychometrics ; Quality of Life ; Reproducibility of Results
Publicat a:	PloS one, Vol. 16 Núm. 7 July (july 2021) , p. e0255317, ISSN 1932-6203

DOI: 10.1371/journal.pone.0255317
PMID: 34324586

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