Prognostic role of intraparotid lymph node metastasis in primary parotid cancer : Systematic review
Guntinas-Lichius, Orlando (Multidisciplinary Salivary Gland Society)
Thielker, Jovanna (Jena University Hospital. Friedrich Schiller University)
Robbins, K.Thomas (Southern Illinois University)
Olsen, Kerry D. (Mayo Clinic)
Shaha, Ashok R. (Memorial Sloan-Kettering Cancer Center (Nova York, Estats Units d'Amèrica))
Mäkitie, Antti A. (Karolinska University Hospital and Karolinska Institutet (Suècia))
de Bree, Remco (University Medical Center Utrecht)
Vander Poorten, Vincent (University Hospitals Leuven (Bèlgica))
Quer, Miquel (Institut d'Investigació Biomèdica Sant Pau)
Rinaldo, Alessandra (University of Udine School of Medicine)
Kowalski, Luiz Paulo (Sao Paulo State University Medical School)
Rodrigo, Juan Pablo (Hospital Universitario Central de Asturias. Instituto Universitario de Oncología del Principado de Asturias. Universidad de Oviedo)
Hamoir, Marc (St Luc University Hospital and King Albert II Cancer Institute. Brussels. Belgium; Institut de Recherche Expérimentale et Clinique (IREC). Université Catholique de Louvain)
Ferlito, Alfio (Coordinator of the International Head and Neck Scientific Group)

Date:	2021
Abstract:	Background: The prognostic importance of intraparotid lymph node metastasis (P+) in patients with primary parotid gland carcinoma is unclear. Methods: Nineteen retrospective and noncomparative cohort studies, published between 1992 and 2020, met the inclusion criteria and included 2202 patients for this systematic review. Results: The pooled prevalence of the P in adult patients in the unselected studies was 24. 10% (95% confidence interval = 17. 95-30. 25). The number of P+ lymph nodes per patient was counted in only three studies and ranged from 1 to 11. The 5-year recurrence-free survival rate based on Kaplan-Meier analysis varied from 83% to 88% in P− patients compared to 36% to 54% in P+ patients. The average hazard ratio for tumor recurrence in patients with P+ compared to P− was 2. 67 ± 0. 58. Conclusions: P+ is an independent negative prognostic factor in primary parotid gland cancer and should be included into the treatment planning.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article de revisió ; recerca ; Versió publicada
Subject:	Clinical significance ; Intraparotid lymph node metastasis ; Nodal metastasis ; Prevalence ; Primary parotid cancer ; Survival
Published in:	Head and Neck, Vol. 43 Núm. 3 (march 2021) , p. 997-1008, ISSN 1097-0347

DOI: 10.1002/hed.26541
PMID: 33169420

12 p, 1.4 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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