Prognostic role of tapse to pasp ratio in patients undergoing mitraclip procedure
Trejo-Velasco, Blanca (Instituto de Investigación Biomédica de Salamanca)
Estevez-Loureiro, Rodrigo (Hospital Álvaro Cunqueiro (Vigo))
Carrasco-Chinchilla, Fernando (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Fernández-Vázquez, Felipe (Hospital Universitario de León)
Arzamendi, Dabit (Institut d'Investigació Biomèdica Sant Pau)
Pan Álvarez-Ossorio, Manuel (Instituto Maimónides de Investigación Biomédica de Córdoba)
Pascual, Isaac (Hospital Universitario de Oviedo)
Nombela-Franco, Luís (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Amat-Santos, Ignacio J (Hospital Universitario de Valladolid)
Freixa, Xavier (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Hernández-Antolín, Rosa Ana (Hospital Universitario Ramón y Cajal (Madrid))
Trillo-Nouche, Ramiro (Hospital Universitario de Santiago)
Ikazuriaga, L.A. (Hospital de Basurto)
López-Mínguez, José Ramón (Hospital Universitario de Badajoz)
Cervera, Dario Sanmiguel (Hospital Universitario de Valencia)
Sanchis, Juan (Hospital Universitario de Valencia)
Diez-Gil, José Luís (Hospital Universitari i Politècnic La Fe (València))
Ruiz-Quevedo, Valeriano (Hospital Universitario de Navarra)
Urbano-Carrillo, Cristóbal A. (Hospital Regional Universitario de Málaga)
Becerra-Muñoz, Víctor Manuel (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Benito-González, Tomás (Hospital Universitario de León)
Li, Chi Hion (Institut d'Investigació Biomèdica Sant Pau)
Mesa, Dolores (Instituto Maimónides de Investigación Biomédica de Córdoba)
Avanzas, Pablo (Hospital Universitario de Oviedo)
Armijo, Germán (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Serrador-Frutos, Ana María (Hospital Universitario de Valladolid)
Sanchis, Laura (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Fernández-Golfín, Covadonga (Hospital Universitario Ramón y Cajal (Madrid))
Cid-Álvarez, Belén (Hospital Universitario de Santiago)
Hernández-García, José María (Centro de Investigación Biomédica en Red en Enfermedades Cardiovasculares)
Garrote-Coloma, Carmen (Hospital Universitario de León)
Fernández-Peregrina, Estefanía (Institut d'Investigació Biomèdica Sant Pau)
Romero, Miguel A. (Instituto Maimónides de Investigación Biomédica de Córdoba)
Argüero, Víctor León (Hospital Universitario de Oviedo)
Cruz-González, Ignacio (Hospital Universitario de Salamanca)

Date:	2021
Abstract:	Background: Transcatheter mitral valve repair (TMVR) is an effective therapy for high-risk patients with severe mitral regurgitation (MR) but heart failure (HF) readmissions and death remain substantial on mid-term follow-up. Recently, right ventricular (RV) to pulmonary arterial (PA) coupling has emerged as a relevant prognostic predictor in HF. In this study, we aimed to assess the prognostic value of tricuspid annular plane systolic excursion (TAPSE) to PA systolic pressure (PASP) ratio as a non-invasive measure of RV-to-PA coupling in patients undergoing TMVR with MitraClip (Abbott, CA, USA). Methods: Multicentre registry including 228 consecutive patients that underwent successful TMVR with MitraClip. The sample was divided in two groups according to TAPSE/PASP median value: 0. 35. The primary combined endpoint encompassed HF readmissions and all-cause mortality. Results: Mean age was 72. 5 ± 11. 5 years and 154 (67. 5%) patients were male. HF readmissions and all-cause mortality were more frequent in patients with TAPSE/PASP ≤ 0. 35: Log-Rank 8. 844, p = 0. 003. On Cox regression, TAPSE/PASP emerged as a prognostic predictor of the primary combined endpoint, together with STS-Score. TAPSE/PASP was a better prognostic predictor than either TAPSE or PASP separately. Conclusions: TAPSE/PASP ratio appears as a novel prognostic predictor in patients undergoing MitraClip implantation that might improve risk stratification and candidate selection.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	MitraClip ; Mitral valve repair ; Mitral valve regurgitation ; Pulmonary hypertension ; Right ventricular to pulmonary arterial coupling ; Transthoracic echocardiography
Published in:	Journal of clinical medicine, Vol. 10 Núm. 5 (january 2021) , p. 1-13, ISSN 2077-0383

DOI: 10.3390/jcm10051006
PMID: 33801311

13 p, 803.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
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