Predictors of loss of functional independence in parkinson's disease : Results from the coppadis cohort at 2-year follow-up and comparison with a control group
Santos García, Diego (Complejo Hospitalario Universitario de A Coruña)
de Deus Fonticoba, Teresa (Complejo Hospitalario Universitario de Ferrol)
Cores Bartolomé, Carlos (Complejo Hospitalario Universitario de A Coruña)
Naya Ríos, Lucía (Complejo Hospitalario Universitario de A Coruña)
García Roca, Lucía (Complejo Hospitalario Universitario de A Coruña)
Martínez Miró, Cristina (Complejo Hospitalario Universitario de A Coruña)
Canfield Medina, H (Complejo Hospitalario Universitario de A Coruña)
Jesús, Silvia (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Aguilar Barberà, Miquel (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Pastor, Pau (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Cosgaya, Marina (Hospital Clínic i Provincial de Barcelona)
García Caldentey, Juan
Caballol, Nuria (Hospital de Sant Joan Despí Moisès Broggi)
Legarda, Inés (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernández-Vara, Jorge (Hospital Universitari Vall d'Hebron)
Cabo-Lopez, Iria (Complejo Hospitalario Universitario de Pontevedra)
López Manzanares, Lydia (Hospital Universitario de la Princesa (Madrid))
Gonzalez-Aramburu, Isabel (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Ávila, Asunción (Consorci Sanitari Integral. Hospital General de L'Hospitalet. L'Hospitalet de Llobregat)
Gómez Mayordomo, Víctor (Hospital Universitario Clínico San Carlos (Madrid))
Nogueira, Víctor (Hospital Da Costa)
Puente, Víctor (Hospital del Mar (Barcelona, Catalunya))
Dotor, Julio (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Borrué, Carmen (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Solano Vila, Berta (Institut Català de la Salut)
Álvarez Sauco, María (Hospital General Universitario de Elche)
Vela, Lydia (Hospital Universitario Fundación Alcorcón)
Escalante, Sonia (Hospital de Tortosa Verge de la Cinta)
Cubo, Esther (Complejo Asistencial Universitario de Burgos)
Carrillo Padilla, Francisco (Hospital Universitario de Canarias (La Laguna))
Martínez-Castrillo, Juan Carlos (Hospital Universitario Ramón y Cajal (Madrid))
Sánchez Alonso, Pilar (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Alonso Losada, Maria G. (Hospital Álvaro Cunqueiro (Vigo))
López Ariztegui, Nuria (Complejo Hospitalario de Toledo)
Gastón, Itziar (Complejo Hospitalario de Navarra)
Kulisevsky, Jaime (Institut d'Investigació Biomèdica Sant Pau)
Blázquez Estrada, Marta (Hospital Universitario Central de Asturias)
Seijo, Manuel (Complejo Hospitalario Universitario de Pontevedra)
Ruíz Martínez, Javier (Hospital Universitario de Donostia (Sant Sebastià, País Basc))
Valero, Caridad (Hospital Arnau de Vilanova (València))
Kurtis, Mónica (Hospital Ruber Internacional)
Fàbregues-Boixar i Nebot, Oriol de (Hospital Universitari Vall d'Hebron)
González Ardura, Jessica (Hospital Universitario de Cabueñes (Gijón))
Alonso Redondo, Ruben (Universitario Lucus Augusti (HULA))
Ordás, Carlos (Hospital Universitario Rey Juan Carlos (Madrid))
López Díaz, Luis M. (Complejo Hospitalario Universitario de Ourense)
McAfee, Darrian (Laboratory for Cognition and Neural Stimulation. Univeristy of Pennsylvania)
Martinez-Martin, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Mir, Pablo (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)

Data:	2021
Resum:	Background and objective: The aim of this study was to compare the progression of independence in activities of daily living (ADL) in Parkinson's disease (PD) patients versus a control group, as well as to identify predictors of disability progression and functional dependency (FD). Patients and Methods: PD patients and control subjects, who were recruited from 35 centers of Spain from the COPPADIS cohort between January 2016 and November 2017 (V0), were included. Patients and subjects were then evaluated again at the 2-year follow-up (V2). Disability was assessed with the Schwab & England Activities of Daily Living Scale (S&E-ADLS) at V0 and V2. FD was defined as an S&E-ADLS score less than 80%. Results: In the PD group, a significant decrease in the S&E-ADLS score from V0 to V2 (N = 507; from 88. 58 ± 10. 19 to 84. 26 ± 13. 38; p < 0. 0001; Cohen's effect size = −0. 519) was observed but not in controls (N = 124; from 98. 87 ± 6. 52 to 99. 52 ± 2. 15; p = 0. 238). When only patients considered functional independent at baseline were included, 55 out of 463 (11. 9%) converted to functional dependent at V2. To be a female (OR = 2. 908; p = 0. 009), have longer disease duration (OR = 1. 152; p = 0. 002), have a non-tremoric motor phenotype at baseline (OR = 3. 574; p = 0. 004), have a higher score at baseline in FOGQ (OR = 1. 244; p < 0. 0001) and BDI-II (OR = 1. 080; p = 0. 008), have a lower score at baseline in PD-CRS (OR = 0. 963; p = 0. 008), and have a greater increase in the score from V0 to V2 in UPDRS-IV (OR = 1. 168; p = 0. 0. 29), FOGQ (OR = 1. 348; p < 0. 0001) and VAFS-Mental (OR = 1. 177; p = 0. 013) (adjusted R-squared 0. 52; Hosmer and Lemeshow test = 0. 94) were all found to be independent predictors of FD at V2. Conclusions: In conclusion, autonomy for ADL worsens in PD patients compared to controls. Cognitive impairment, gait problems, fatigue, depressive symptoms, more advanced disease, and a non-tremor phenotype are independent predictors of FD in the short-term.
Nota:	Altres ajuts: Fundación Curemos el Parkinson.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Activities of daily living ; Dependency ; Disability ; Gait ; Parkinson's disease
Publicat a:	Diagnostics, Vol. 11 Núm. 10 (october 2021) , p. 1801, ISSN 2075-4418

DOI: 10.3390/diagnostics11101801
PMID: 34679503

26 p, 1.3 MB

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