The importance of maternal insulin resistance throughout pregnancy on neonatal adiposity
Lima, Rodrigo A. (University of Graz. Institution of Sport Science)
Desoye, Gernot (Medical University of Graz. Department of Obstetrics and Gynaecology)
Simmons, David (Addenbrookes Hospital (Cambridge, Regne Unit))
Devlieger, Roland (Gynaecology and Obstetrics. University Hospitals Leuven)
Galjaard, Sander (University Medical Centre Rotterdam. Department of Obstetrics and Gynaecology, Division of Obstetrics and Prenatal Medicine)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Adelantado, Juan M.. (Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina)
Dunne, Fidelma (Galway Diabetes Research Centre and College of Medicine Nursing and Health Sciences. National University of Ireland)
Harreiter, Jürgen (Medical University of Vienna)
Kautzky-Willer, Alexandra (Medical University of Vienna)
Damm, Peter (University of Copenhagen. Department of Clinical Medicine, Faculty of Health and Medical Sciences)
Mathiesen, Elisabeth R. (Institute of Clinical Medicine. University of Copenhagen)
Jensen, Dorte M (University of Southern Denmark. Department of Clinical Research)
Andersen, Lise-Lotte (University of Southern Denmark. Department of Clinical Research)
Tanvig, Mette (University of Southern Denmark. Department of Clinical Research)
Lapolla, Annunziata (Universita Degli Studi di Padova)
Dalfra, Maria Grazia (Universita Degli Studi di Padova)
Bertolotto, Alessandra (Azienda Ospedaliero Universitaria - Pisa)
Manta, Urszula (Poznan University of Medical Sciences)
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, David J. (Recherche en Santé Lawson SA)
Snoek, Frank J. (Amsterdam Public Health Research Institute)
Jelsma, Judith G. M (Amsterdam Public Health Research Institute)
van Poppel, Mireille (University of Graz. Institution of Sport Science)

Data:	2021
Resum:	Background: Although previous studies evaluated the association of maternal health parameters with neonatal adiposity, little is known regarding the complexity of the relationships among different maternal health parameters throughout pregnancy and its impact on neonatal adiposity. Objectives: To evaluate the direct and indirect associations between maternal insulin resistance during pregnancy, in women with obesity, and neonatal adiposity. In addition, associations between maternal fasting glucose, triglycerides (TG), non-esterified fatty acids (NEFA), and neonatal adiposity were also assessed. Methods: This is a longitudinal, secondary analysis of the DALI study, an international project conducted in nine European countries with pregnant women with obesity. Maternal insulin resistance (HOMA-IR), fasting glucose, TG, and NEFA were measured three times during pregnancy (<20, 24-28, and 35-37 weeks of gestation). Offspring neonatal adiposity was estimated by the sum of four skinfolds. Structural equation modelling was conducted to evaluate the direct and indirect relationships among the variables of interest. Results: Data on 657 mother-infant pairs (50. 7% boys) were analysed. Neonatal boys exhibited lower mean sum of skinfolds compared to girls (20. 3 mm, 95% CI 19. 7, 21. 0 vs 21. 5 mm, 95% CI 20. 8, 22. 2). In boys, maternal HOMA-IR at <20 weeks was directly associated with neonatal adiposity (β = 0. 35 mm, 95% CI 0. 01, 0. 70). In girls, maternal HOMA-IR at 24-28 weeks was only indirectly associated with neonatal adiposity, which implies that this association was mediated via maternal HOMA-IR, glucose, triglycerides, and NEFA during pregnancy (β = 0. 26 mm, 95% CI 0. 08, 0. 44). Conclusions: The timing of the role of maternal insulin resistance on neonatal adiposity depends on fetal sex. Although the association was time-dependent, maternal insulin resistance was associated with neonatal adiposity in both sexes.
Ajuts:	European Commission 242187
Nota:	Altres ajuts: Netherlands Organisation for Health Research and Development (ZonMw grant 200310013); Polish Ministry of Science (grants 2203/7, PR/2011/2); Odense University Free Research Fund; Consorcio de Apoyo a la Investigación Biomédica en Red (CAIBER 1527-B-226).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Endocrinology ; Gynaecology ; Insulin ; Lipid metabolism ; Obesity
Publicat a:	Paediatric and Perinatal Epidemiology, Vol. 35 Núm. 1 (january 2021) , p. 83-91, ISSN 1365-3016

DOI: 10.1111/ppe.12682
PMID: 32352590

9 p, 380.0 KB

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