Ageing meets kidney disease
Ortiz, Alberto (Universidad Autónoma de Madrid. Departamento de Medicina)
Mattace-Raso, Francesco (Erasmus MC University Medical Center)
Soler, María José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fouque, Denis (Université de Lyon)
Universitat Autònoma de Barcelona. Departament de Cirurgia

Date:	2022
Abstract:	Chronic kidney disease (CKD) is defined as abnormalities of kidney structure or function, present for ˃3 months, with implications for health. The most used diagnostic criteria are a urinary albumin: creatinine ratio ≥30 mg/g or an estimated glomerular filtration rate (eGFR) <60 mL/min/1. 73 m 2. Either of these diagnostic thresholds is associated with adverse health outcomes. GFR decreases with age and the prevalence of CKD is highest in older adults; moreover, the presence of CKD is associated with an increased risk of all-cause and cardiovascular death related to accelerated ageing in all age ranges, and the absolute increase in risk is highest for those aged ˃75 years. Indeed, premature death is a more common outcome than CKD progression to kidney failure requiring kidney replacement therapy. The progressive ageing of the world population contributes to the projection that CKD will become the second most common cause of death before the end of the century in countries with long life expectancy. The current collection of selected studies on kidney disease and ageing published in Age&Ageing, NDT and CKJ provides an overview of key topics, including cognitive decline, sarcopaenia, wasting and cardiovascular and non-cardiovascular morbidity and mortality, the management of kidney failure and gender differences in CKD progression.
Grants:	Instituto de Salud Carlos III RD21/0005/0001 Instituto de Salud Carlos III RD21/0005/0016
Note:	Aquest article es va publicar de forma simultània a tres publicacions: Clinical Kidney Journal, Nephrology Dialysis Transplantation i Age and Ageing
Note:	Altres ajuts: Fundació la Marató de TV3
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Nephrology Dialysis Transplantation, Vol. 38 (june 2022) , p. 523-526, ISSN 1460-2385

DOI: 10.1093/ndt/gfac199
DOI: 10.1093/ckj/sfac151
DOI: 10.1093/ageing/afac157
PMID: 35768068
PMID: 36158151

5 p, 310.7 KB

The record appears in these collections:
Articles > Research articles
Articles > Published articles