Cross interactions between Apolipoprotein E and amyloid proteins in neurodegenerative diseases
Loch, Rolf Antonie (Scherrer Institute (Suïssa). Department of Biology and Chemistry)
Wang, Hongzhi (Paul Scherrer Institute (Suïssa). Department of Biology and Chemistry)
Peralvarez-Marin, Alex (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular)
Berger, Philipp (Scherrer Institute (Suïssa). Department of Biology and Chemistry)
Nielsen, Henrietta (Stockholm University. Department of Biochemistry and Biophysics)
Chroni, Angeliki (National Center for Scientific Research 'Demokritos' (Grècia))
Luo, Jinghui (Scherrer Institute (Suïssa). Department of Biology and Chemistry)

Date:	2023
Abstract:	Three common Apolipoprotein E isoforms, ApoE2, ApoE3, and ApoE4, are key regulators of lipid homeostasis, among other functions. Apolipoprotein E can interact with amyloid proteins. The isoforms differ by one or two residues at positions 112 and 158, and possess distinct structural conformations and functions, leading to isoform-specific roles in amyloid-based neurodegenerative diseases. Over 30 different amyloid proteins have been found to share similar characteristics of structure and toxicity, suggesting a common interactome. The molecular and genetic interactions of ApoE with amyloid proteins have been extensively studied in neurodegenerative diseases, but have not yet been well connected and clarified. Here we summarize essential features of the interactions between ApoE and different amyloid proteins, identify gaps in the understanding of the interactome and propose the general interaction mechanism between ApoE isoforms and amyloid proteins. Perhaps more importantly, this review outlines what we can learn from the interactome of ApoE and amyloid proteins; that is the need to see both ApoE and amyloid proteins as a basis to understand neurodegenerative diseases.
Grants:	Agencia Estatal de Investigación PID2020-120222GB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	ApoE ; Amyloid proteins ; Interaction ; Endogenous molecules ; Cytotoxicity ; Therapeutics
Published in:	Computational and Structural Biotechnology Journal, Vol. 21 (january 2023) , p. 1189-1204, ISSN 2001-0370

DOI: 10.1016/j.csbj.2023.01.022
PMID: 36817952

16 p, 3.1 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Neurociències (INc)
Articles > Research articles
Articles > Published articles