Extracellular vesicles, the emerging mirrors of brain physiopathology
Cano, Amanda (Ace Alzheimer Center Barcelona)
Ettcheto, Miren (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Bernuz, Mireia (Universitat Autònoma de Barcelona. Departament de Química)
Puerta, Raquel (Ace Alzheimer Center Barcelona)
Esteban de Antonio, Ester (Ace Alzheimer Center Barcelona)
Sánchez-López, Elena (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas)
Souto, Eliana B. (Universidade do Porto. Faculdade de Farmácia)
Camins, Antoni (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica)
Martí, Mercè (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Pividori, María Isabel (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Boada, Mercè (Ace Alzheimer Center Barcelona)
Ruiz, Agustín (Ace Alzheimer Center Barcelona)

Date:	2023
Abstract:	Extracellular vesicles are secreted by a wide variety of cells, and their primary functions include intercellular communication, immune responses, human reproduction, and synaptic plasticity. Their molecular cargo reflects the physiological processes that their cells of origin are undergoing. Thus, many studies have suggested that extracellular vesicles could be a promising biomarker tool for many diseases, mainly due to their biological relevance and easy accessibility to a broad range of body fluids. Moreover, since their biological composition leads them to cross the blood-brain barrier bidirectionally, growing evidence points to extracellular vesicles as emerging mirrors of brain diseases processes. In this regard, this review explores the biogenesis and biological functions of extracellular vesicles, their role in different physiological and pathological processes, their potential in clinical practice, and the recent outstanding studies about the role of exosomes in major human brain diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or brain tumors.
Grants:	Ministerio de Ciencia e Innovación PID2021-122473OA-I00 Ministerio de Ciencia e Innovación PID2021-123462OB-I00 Agencia Estatal de Investigación PID2019-106625RB-I00 Instituto de Salud Carlos III CD22/00125 Instituto de Salud Carlos III PI17/01474 Instituto de Salud Carlos III PI19/00335 Instituto de Salud Carlos III PI22/01403 Instituto de Salud Carlos III PI22/00258 Instituto de Salud Carlos III CB06/05/2004 Instituto de Salud Carlos III CB18/05/00010
Note:	Altres ajuts: The support of Fundación bancaria "La Caixa" and Grífols SA (GR@ACE project).
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Exosomes ; Extracellular vesicles ; Alzheimer's disease ; Parkinson's disease ; Glioblastoma ; Multiple sclerosis, amyotrophic lateral sclerosis ; Neurodegenerative diseases
Published in:	International journal of biological sciences, Vol. 19, issue 3 (2023) , p. 721-743, ISSN 1449-2288

DOI: 10.7150/ijbs.79063
PMID: 36778117

23 p, 2.5 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles