Effects of lateral size, thickness, and stabilizer concentration on the cytotoxicity of defect-free graphene nanosheets : implications for biological applications
Hu, Chen-Xia (University of Manchester. Department of Chemistry)
Read, Oliver (University of Manchester. Department of Chemistry)
Shin, Yuyoung (University of Manchester. Department of Chemistry)
Chen, Yingxian (University of Manchester. Nanomedicine Lab)
Wang, Jingjing (University of Manchester. Department of Chemistry)
Boyes, Matthew (University of Manchester. Department of Chemistry)
Zeng, Niting (University of Manchester. Department of Chemistry)
Panigrahi, Adyasha (University of Manchester. Department of Chemistry)
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Larrosa, Igor (University of Manchester. Department of Chemistry)
Vranic, Sandra (University of Manchester. Nanomedicine Lab)
Casiraghi, Cinzia (University of Manchester. Department of Chemistry)

Data:	2022
Resum:	In this work, we apply liquid cascade centrifugation to highly concentrated graphene dispersions produced by liquid-phase exfoliation in water with an insoluble bis-pyrene stabilizer to obtain fractions containing nanosheets with different lateral size distributions. The concentration, stability, size, thickness, and the cytotoxicity profile are studied as a function of the initial stabilizer concentration for each fraction. Our results show that there is a critical initial amount of stabilizer (0. 4 mg/mL) above which the dispersions show reduced concentration, stability, and biocompatibility, no matter the lateral size of the flakes.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Graphene ; Liquid-phase exfoliation ; Pyrene ; Biocompatibility ; Atomic force microscopy ; Size-thickness characterization
Publicat a:	ACS applied nano materials, Vol. 5, issue 9 (Sep. 2022) , p. 12626-12636, ISSN 2574-0970

DOI: 10.1021/acsanm.2c02403
PMID: 36185165

11 p, 9.3 MB

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