Triazine mediated covalent antibiotic grafting on cotton fabrics as a modular approach for developing antimicrobial barriers
Montagut, Ana Maria (Universitat Autònoma de Barcelona. Departament de Química)
Granados Toda, Albert (Universitat Autònoma de Barcelona. Departament de Química)
Lazurko, Caitlin (University of Ottawa. Department of Biochemistry, Microbiology and Immunology)
El-Khoury, Antony (University of Ottawa Heart Institute. Division of Cardiac Surgery)
Suuronen, Erik J. (University of Ottawa Heart Institute. Division of Cardiac Surgery)
Alarcón-Martín, Emilio (University of Ottawa Heart Institute. Division of Cardiac Surgery)
Sebastián Pérez, Rosa Maria (Universitat Autònoma de Barcelona. Departament de Química)
Vallribera Massó, Adelina (Universitat Autònoma de Barcelona. Departament de Química)

Data:	2019
Resum:	New antimicrobial textiles were prepared through direct chemical linkage of bioactive molecules eugenol and fluoroquinolone derivatives, onto the surface of cotton fabrics. The attachment through a triazine moiety minimizes the leaching of the antimicrobial molecule into the surroundings of the material. Bacterial efficacy against Staphylococcus aureus and Pseudomonas aeruginosa was studied. The treated textile with fluoroquinolone demonstrated bacteriostatic antimicrobial effects having a tendency to decrease the population of S. aureus in the planktonic form. A significant effect was also observed in the prevention of S. aureus biofilm formation and in its ability to kill bacteria within a preformed biofilm. Eugenol-modified fabric was also active in the process of eradicating preformed P. aeruginosa biofilms. Further, in vitro assays using human dermal fibroblast cells indicate no effects on cell proliferation and viability, and in vivo tests in a murine skin wound model showed no increase of IL-6 for full-thickness wounds that were in contact with the fabrics.
Ajuts:	Ministerio de Economía y Competitividad CTQ2014-53662-P Agencia Estatal de Investigación RTI2018-097853-B-I00 Ministerio de Economía y Competitividad 2016-81797-REDC Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-00465
Drets:	Tots els drets reservats.
Llengua:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Matèria:	Microbicidal ; Cotton fabrics ; Covalent functionalization ; Fluoroquinolone ; Biocompatibility ; Biofilm destruction
Publicat a:	Cellulose, Vol. 26, Issue 12 (August 2019) , p. 7495-7505, ISSN 1572-882X

DOI: 10.1007/s10570-019-02584-w

Postprint 21 p, 990.8 KB

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