Squaramide-based Pt(II) complexes as potential oxygen-regulated light-triggered photocages
Morales Fernández, Kevin (Universitat Autònoma de Barcelona. Departament de Química)
Samper, Katia G. (Universitat Autònoma de Barcelona. Departament de Química)
Peña, Quim (Universitat Autònoma de Barcelona. Departament de Química)
Hernando Campos, Jordi (Universitat Autònoma de Barcelona. Departament de Química)
Lorenzo Rivera, Julia (Universitat Autònoma de Barcelona. Institut de Biotecnologia i de Biomedicina "Vicent Villar Palasí")
Rodríguez-Diéguez, Antonio (Universidad de Granada. Departamento de Química Inorgánica)
Capdevila Vidal, Mercè (Universitat Autònoma de Barcelona. Departament de Química)
Figueredo Galimany, Marta (Universitat Autònoma de Barcelona. Departament de Química)
Palacios Bonilla, Òscar (Universitat Autònoma de Barcelona. Departament de Química)
Bayón, Joan Carles (Universitat Autònoma de Barcelona. Departament de Química)
Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular

Date:	2018
Abstract:	Two new squaramide-based platinum(II) complexes C1 and C2 have been synthesized and fully characterized. Their photoresponse has been assessed and is discussed. A remarkable enhancement in the DNA binding activity has been observed for both complexes, up on irradiation. For C2, the release of Pt(II) provoked by its irradiation has been studied. The response of C2 has been found to be regulated by the presence of oxygen. In vitro cytotoxicity tests show an enhancement in the activity of complex C2 after selective irradiation under hypoxic conditions. Resulting Pt(II) species have been isolated and characterized by various analytical methods establishing this type of squaramido-based complexes as a proof of concept for new Pt(II) photocages.
Grants:	Ministerio de Ciencia e Innovación CTQ2010-15380 Ministerio de Economía y Competitividad CTQ2013-41161-R Ministerio de Economía y Competitividad BIO2015-67358-C2-2-P
Rights:	Tots els drets reservats.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Published in:	Inorganic chemistry, Vol. 57, Issue 24 (December 2018) , p. 15517-15525, ISSN 1520-510X

DOI: 10.1021/acs.inorgchem.8b02854
PMID: 30495945

Postprint 27 p, 943.8 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Group in Electrochemistry, Photochemistry and Organic Reactivity (GEFRO)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Biotecnologia i de Biomedicina (IBB)
Articles > Research articles
Articles > Published articles