Epidemiology, Diagnosis and Management of Penile Cancer : Results from the Spanish National Registry of Penile Cancer
Borque-Fernando, Ángel (Hospital Universitario Miguel Servet (Saragossa))
Gaya, Josep Maria (Fundació Puigvert)
Esteban, Luis M (Universidad de Zaragoza. Departamento de Matemática Aplicada)
Gómez-Rivas, Juan (Hospital Universitario La Paz (Madrid))
García-Baquero, Rodrigo (Hospital Universitario Puerta del Mar (Cadis, Andalusia))
Agreda Castañeda, Fernando (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gallioli, Andrea (Institut de Recerca Sant Pau)
Verri, Paolo (Fundació Puigvert)
Ortiz-Vico, Francisco Javier (Hospital Universitario Príncipe de Asturias (Alcalá de Henares, Madrid))
Amir-Nicolau, Balig Fawwaz (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Osman-Garcia, Ignacio (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Gil-Martínez, Pedro (Hospital Universitario Miguel Servet (Saragossa))
Arrabal-Martín, Miguel (Complejo Hospitalario Universitario de Granada)
Gómez-Ferrer Lozano, Álvaro (Instituto Valenciano de Urologia (IVO))
Campos-Juanatey, Felix (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Guerrero-Ramos, Félix (Hospital Universitario 12 de Octubre (Madrid))
Rubio-Briones, Josè (Hospital Vithas Valencia 9 de Octubre)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	Penile cancer is a rare malignant tumor mainly affecting adult/older men. Given the rarity of this disease, affecting 1/100,000 men every year, risk factors and diagnostic procedures are often inadequately described. This is the first multicenter study to describe the approach to this disease in Spain. The results highlight the need for the institution of referral centers and standardized diagnostic pathways for the optimal management of this disease. Introduction: Penile cancer (PC) is a rare malignancy with an overall incidence in Europe of 1/100,000 males/year. In Europe, few studies report the epidemiology, risk factors, clinical presentation, and treatment of PC. The aim of this study is to present an updated outlook on the aforementioned factors of PC in Spain. Materials and Methods: A multicentric, retrospective, observational epidemiological study was designed, and patients with a new diagnosis of PC in 2015 were included. Patients were anonymously identified from the Register of Specialized Care Activity of the Ministry of Health of Spain. All Spanish hospitals recruiting patients in 2015 were invited to participate in the present study. We have followed a descriptive narration of the observed data. Continuous and categorical data were reported by median (p25th-p75th range) and absolute and relative frequencies, respectively. The incidence map shows differences between Spanish regions. Results: The incidence of PC in Spain in 2015 was 2. 55/100,000 males per year. A total of 586 patients were identified, and 228 patients from 61 hospitals were included in the analysis. A total of 54/61 (88. 5%) centers reported ≤ 5 new cases. The patients accessed the urologist for visually-assessed penile lesions (60. 5%), mainly localized in the glans (63. 6%). Local hygiene, smoking habits, sexual habits, HPV exposure, and history of penile lesions were reported in 48. 2%, 59. 6%, 25%, 13. 2%, and 69. 7%. HPV-positive lesions were 18. 1% (28. 6% HPV-16). The majority of PC was squamous carcinoma (95. 2%). PC was ≥cT2 in 45. 2% (103/228) cases. At final pathology, PC was ≥pT2 in 51% of patients and ≥pN1 in 17% of cases. The most common local treatment was partial penectomy (46. 9% cases). A total of 47/55 (85. 5%) inguinal lymphadenectomies were open. Patients with ≥pN1 disease were treated with chemotherapy in 12/39 (40. 8%) of cases. Conclusions: PC incidence is relatively high in Spain compared to other European countries. The risk factors for PC are usually misreported. The diagnosis and management of PC are suboptimal, encouraging the identification of referral centers for PC management.
Ajuts:	Ministerio de Ciencia e Innovación PID2020-116873GB-I00 Agencia Estatal de Investigación PID2020-116873GB-I00
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Penile cancer ; Cancer ; Epidemiology ; Incidence
Publicat a:	Cancers, Vol. 15 (january 2023) , ISSN 2072-6694

DOI: 10.3390/cancers15030616
PMID: 36765574

12 p, 940.6 KB

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