Retinal inner nuclear layer volume reflects inflammatory disease activity in multiple sclerosis; a longitudinal OCT study
Balk, Lisanne J. (Vrije Universiteit Amsterdam)
Coric, Danko (Vrije Universiteit Amsterdam)
Knier, Benjamin (Technische Universität München)
Zimmermann, Hanna G. (Charité - Universitätsmedizin Berlin)
Behbehani, Raed (Ibn Sina Hospital, Kuwait)
Alroughani, Raed (Amiri Hospital, Kuwait)
Martinez-Lapiscina, Elena H. (Hospital Clínic i Provincial de Barcelona)
Brandt, Alexander U. (Charité - Universitätsmedizin Berlin)
Sánchez-Dalmau, Bernardo (Hospital Clínic i Provincial de Barcelona)
Vidal-Jordana, Angela (Hospital Universitari Vall d'Hebron)
Albrecht, Philipp (Heinrich Heine University)
Koska, Valeria (Heinrich Heine University)
Havla, Joachim (Ludwig-Maximilians Universitaet Muenchen)
Pisa, Marco (Vita-Salute San Raffaele University)
Nolan, Rachel C. (New York University School of Medicine)
Leocani, Letizia (Vita-Salute San Raffaele University)
Paul, Friedemann (Max Delbrueck Center for Molecular Medicine and Charité - Universitätsmedizin Berlin)
Aktas, Orhan (Heinrich Heine University)
Montalban, Xavier (Hospital Universitari Vall d'Hebron)
Balcer, Laura J. (New York University School of Medicine)
Villoslada, Pablo (Hospital Clínic i Provincial de Barcelona)
Outteryck, Olivier (Université Lille)
Korn, Thomas (Munich Cluster for Systems Neurology (SyNergy))
Petzold, Axel (Moorfields Eye Hospital & The National Hospital for Neurology and Neurosurgery)
Universitat Autònoma de Barcelona. Departament de Medicina

Data:	2019
Resum:	Background: The association of peripapillary retinal nerve fibre layer (pRNFL) and ganglion cell-inner plexiform layer (GCIPL) thickness with neurodegeneration in multiple sclerosis (MS) is well established. The relationship of the adjoining inner nuclear layer (INL) with inflammatory disease activity is less well understood. Objective: The objective of this paper is to investigate the relationship of INL volume changes with inflammatory disease activity in MS. Methods In this longitudinal, multi-centre study, optical coherence tomography (OCT) and clinical data (disability status, relapses and MS optic neuritis (MSON)) were collected in 785 patients with MS (68. 3% female) and 92 healthy controls (63. 4% female) from 11 MS centres between 2010 and 2017 and pooled retrospectively. Data on pRNFL, GCIPL and INL were obtained at each centre. Results: There was a significant increase in INL volume in eyes with new MSON during the study (N = 61/1562, β = 0. 01 mm, p <. 001). Clinical relapses (other than MSON) were significantly associated with increased INL volume (β = 0. 005, p =. 025). INL volume was independent of disease progression (β = 0. 002 mm, p =. 474). Conclusion: Our data demonstrate that an increase in INL volume is associated with MSON and the occurrence of clinical relapses. Therefore, INL volume changes may be useful as an outcome marker for inflammatory disease activity in MSON and MS treatment trials.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Inflammation ; Inner nuclear layer ; Multiple sclerosis ; Optical coherence tomography
Publicat a:	Multiple Sclerosis Journal - Experimental, Translational and Clinical, Vol. 5 Núm. 3 (2019) , ISSN 2055-2173

DOI: 10.1177/2055217319871582
PMID: 31523449

11 p, 1.0 MB

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