Prognostic effect of body mass index in patients with advanced NSCLC treated with chemoimmunotherapy combinations
Cortellini, Alessio (Imperial College London)
Ricciuti, Biagio (Lowe Center for Thoracic Oncology. Dana Farber Cancer Institute)
Vaz, Victor R. (Lowe Center for Thoracic Oncology. Dana Farber Cancer Institute)
Soldato, Davide (Cancer Medicine Department. Gustave Roussy)
Alessi, Joao V. (Lowe Center for Thoracic Oncology. Dana Farber Cancer Institute)
Dall'olio, Filippo G. (Cancer Medicine Department. Gustave Roussy)
Banna, Giuseppe L. (Candiolo Cancer Institute. FPO-IRCCS)
Muthuramalingam, Sethupathi (Oncology Department. United Lincolnshire Hospital NHS Trust)
Chan, Samuel (Oncology Department. Queen Alexandra University Hospital. Portsmouth Hospitals NHS Trust)
Majem, Margarita (Institut d'Investigació Biomèdica Sant Pau)
Piedra, Aida (Institut d'Investigació Biomèdica Sant Pau)
Lamberti, Giuseppe (Department of Experimental Diagnostic and Specialty Medicine. S. Orsola-Malpighi University Hospital. Alma Mater Studiorum University of Bologna)
Andrini, Elisa (Department of Experimental Diagnostic and Specialty Medicine. S. Orsola-Malpighi University Hospital. Alma Mater Studiorum University of Bologna)
Addeo, Alfredo (Medical Oncology. University Hospital of Geneva)
Friedlaender, Alex (Medical Oncology. University Hospital of Geneva)
Facchinetti, Francesco (Université Paris-Saclay)
Gorriá, Teresa (Hospital Clínic i Provincial de Barcelona)
Mezquita, Laura (Hospital Clínic i Provincial de Barcelona)
Hoton, Delphine (Department of Pathology. Cliniques Universitaires Saint-Luc)
Valerie, Lacroix (Department of Cardiovascular and Thoracic Surgery. IREC. Cliniques Universitaires Saint-Luc)
Nana, Frank Aboubakar (Institut de Recherche Expérimentale et Clinique (IREC). Pôle de Pneumologie. ORL et Dermatologie (PNEU). Université Catholique de Louvain (UCLouvain))
Artingstall, James (Bristol Haematology and Oncology Centre)
Comins, Charles (Bristol Haematology and Oncology Centre)
Di Maio, Massimo (Department of Oncology. University of Turin and Mauriziano Hospital)
Caglio, Andrea (Department of Oncology. University of Turin and Mauriziano Hospital)
Cave, Judith (Department of Medical Oncology. University Hospital Southampton NHS Foundation Trust)
McKenzie, Hayley (Department of Medical Oncology. University Hospital Southampton NHS Foundation Trust)
Newsom-Davis, Thomas (Department of Oncology. National Centre for HIV Malignancies. Chelsea and Westminster Hospital)
Evans, Joanne S. (Imperial College London)
Tiseo, Marcello (Medical Oncology Unit. University Hospital of Parma)
D'Alessio, Antonio (Department of Biomedical Sciences. Humanitas University)
Fulgenzi, Claudia A.M. (Department of Medical Oncology. University Campus Bio-Medico)
Besse, Benjamin (School of Medicine. University Paris-Saclay)
Awad, Mark M. (Lowe Center for Thoracic Oncology. Dana Farber Cancer Institute)
Pinato, David J. (Division of Oncology. Department of Translational Medicine. University of Piemonte Orientale)

Date:	2022
Abstract:	Introduction It has been recognized that increasing body mass index (BMI) is associated with improved outcome from immune checkpoint inhibitors (ICIs) in patients with various malignancies including non-small cell lung cancer (NSCLC). However, it is unclear whether baseline BMI may influence outcomes from first-line chemoimmunotherapy combinations. Methods In this international multicenter study, we evaluated the association between baseline BMI, progression-free survival (PFS) and overall survival (OS) in a cohort of patients with stage IV NSCLC consecutively treated with first-line chemoimmunotherapy combinations. BMI was categorized according to WHO criteria. Results Among the 853 included patients, 5. 3% were underweight; 46. 4% were of normal weight; 33. 8% were overweight; and 14. 5% were obese. Overweight and obese patients were more likely aged ≥70 years (p=0. 00085), never smokers (p<0. 0001), with better baseline Eastern Cooperative Oncology Group - Performance Status (p=0. 0127), and had lower prevalence of central nervous system (p=0. 0002) and liver metastases (p=0. 0395). Univariable analyses showed a significant difference in the median OS across underweight (15. 5 months), normal weight (14. 6 months), overweight (20. 9 months), and obese (16. 8 months) patients (log-rank: p=0. 045, log rank test for trend: p=0. 131), while no difference was found with respect to the median PFS (log-rank for trend: p=0. 510). Neither OS nor PFS was significantly associated with baseline BMI on multivariable analysis. Conclusions In contrast to what was observed in the context of chemotherapy-free ICI-based regimens, baseline BMI does not affect clinical outcomes from chemoimmunotherapy combinations in patients with advanced NSCLC.
Note:	Altres ajuts: The NIHR Imperial College BRC Push for Impact scheme 2019; the European Association for the Study of the Liver (Andrew Burroughs Fellowship); the Society of Immunotherapy of Cancer-AstraZeneca Young Investigator Award; the Wellcome Trust Strategic Fund (PS3416); the Associazione Italiana per la Ricerca sul Cancro (AIRC MFAG Grant ID 25697); the NIHR Imperial Biomedical Research Centre (BRC); the Imperial Experimental Cancer Medicine Centre (ECMC); the Imperial College Tissue Bank. the NIHR Imperial BRC.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal for immunotherapy of cancer, Vol. 10 Núm. 2 (February 2022) , p. e004374, ISSN 2051-1426

DOI: 10.1136/jitc-2021-004374
PMID: 35173031

7 p, 657.6 KB

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