Skin Temperature Circadian Rhythms and Dysautonomia in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome : The Role of Endothelin-1 in the Vascular Tone Dysregulation
Cambras, Trinitat (Universitat de Barcelona)
Zerón-Rugerio, Maria Fernanda (Universitat de Barcelona)
Díez-Noguera, Antoni (Universitat de Barcelona)
Zaragoza, Maria Cleofé (Laboratorios Viñas)
Domingo, Joan Carles (Universitat de Barcelona)
Sanmartin Sentañes, Ramon (Hospital Universitari Vall d'Hebron)
Alegre Martín, José (Hospital Universitari Vall d'Hebron)
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2023
Resum:	There is accumulating evidence of autonomic dysfunction in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS); however, little is known about its association with circadian rhythms and endothelial dysfunction. This study aimed to explore the autonomic responses through an orthostatic test and analysis of the peripheral skin temperature variations and vascular endothelium state in ME/CFS patients. Sixty-seven adult female ME/CFS patients and 48 healthy controls were enrolled. Demographic and clinical characteristics were assessed using validated self-reported outcome measures. Postural changes in blood pressure, heart rate, and wrist temperature were recorded during the orthostatic test. Actigraphy during one week was used to determine the 24-h profile of peripheral temperature and activity. Circulating endothelial biomarkers were measured as indicators of endothelial functioning. Results showed that ME/CFS patients presented higher blood pressure and heart rate values than healthy controls in the supine and standing position (p < 0. 05 for both), and also a higher amplitude of the activity rhythm (p < 0. 01). Circulating levels of endothelin-1 (ET-1) and vascular cell adhesion molecule-1 (VCAM-1) were significantly higher in ME/CFS (p < 0. 05). In ME/CFS, ET-1 levels were associated with the stability of the temperature rhythm (p < 0. 01), and also with the self-reported questionnaires (p < 0. 001). This suggests that ME/CFS patients exhibited modifications in circadian rhythm and hemodynamic measures, which are associated with endothelial biomarkers (ET-1 and VCAM-1). Future investigation in this area is needed to assess dysautonomia and vascular tone abnormalities, which may provide potential therapeutic targets for ME/CFS.
Ajuts:	Instituto de Salud Carlos III PI19/00629 Instituto de Salud Carlos III PI19/00731
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic fatigue syndrome ; Circadian rhythms ; Endothelin-1 ; Myalgic encephalomyelitis ; Skin temperature
Publicat a:	International journal of molecular sciences, Vol. 24 (march 2023) , ISSN 1422-0067

DOI: 10.3390/ijms24054835
PMID: 36902264

18 p, 1.4 MB

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