The Phosphorylation of Kv1.3 : A Modulatory Mechanism for a Multifunctional Ion Channel
Navarro-Pérez, María (Universitat de Barcelona)
Estadella, Irene (Universitat de Barcelona)
Benavente-Garcia, Anna (Universitat de Barcelona)
Orellana-Fernández, Ruth (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Petit Montserrat, Anna (Hospital Universitari de Bellvitge)
Ferreres Piñas, Joan Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Felipe, Antonio (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The voltage-dependent potassium channel Kv1. 3 is a potential target for cancer therapies. This channel exhibits a complex repertoire of physiological functions such as proliferation, activation, insulin sensitivity, nerve action potential and apoptosis among others. Furthermore, the expression and activity of Kv1. 3 remodels in various types of tumors. Kv1. 3 forms heteroligomeric complexes by association with a number of ancillary proteins that fine-tune the function of the complex. In addition, protein kinase signaling networks are essential for comprehending tumorigenesis. Kv1. 3, but also its partners, undergoes phosphorylation-dephosphorylation cycles shaping and remodeling the biology of the channelosome. Therefore, this review compiles protein kinase mechanisms on Kv1. 3 to understand regulatory mechanisms during tumor development. The voltage-gated potassium channel Kv1. 3 plays a pivotal role in a myriad of biological processes, including cell proliferation, differentiation, and apoptosis. Kv1. 3 undergoes fine-tuned regulation, and its altered expression or function correlates with tumorigenesis and cancer progression. Moreover, posttranslational modifications (PTMs), such as phosphorylation, have evolved as rapid switch-like moieties that tightly modulate channel activity. In addition, kinases are promising targets in anticancer therapies. The diverse serine/threonine and tyrosine kinases function on Kv1. 3 and the effects of its phosphorylation vary depending on multiple factors. For instance, Kv1. 3 regulatory subunits (KCNE4 and Kvβ) can be phosphorylated, increasing the complexity of channel modulation. Scaffold proteins allow the Kv1. 3 channelosome and kinase to form protein complexes, thereby favoring the attachment of phosphate groups. This review compiles the network triggers and signaling pathways that culminate in Kv1. 3 phosphorylation. Alterations to Kv1. 3 expression and its phosphorylation are detailed, emphasizing the importance of this channel as an anticancer target. Overall, further research on Kv1. 3 kinase-dependent effects should be addressed to develop effective antineoplastic drugs while minimizing side effects. This promising field encourages basic cancer research while inspiring new therapy development.
Grants:	Agencia Estatal de Investigación BFU2017-87104-R Agencia Estatal de Investigación PID2020-112647RB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	K+ channels ; Cancer ; Phosphorylation
Published in:	Cancers, Vol. 15 (may 2023) , ISSN 2072-6694

DOI: 10.3390/cancers15102716
PMID: 37345053

21 p, 981.7 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles