Cutibacterium spp. Infections after Instrumented Spine Surgery Have a Good Prognosis Regardless of Rifampin Use : A Cross-Sectional Study
Núñez-Pereira, Susana (Hospital Universitari Vall d'Hebron)
Benavent, Eva (Hospital Universitari de Bellvitge)
Ulldemolins, Marta (Hospital Universitari de Bellvitge)
Sobrino-Díaz, Beatriz (Hospital Regional Universitario de Málaga)
Iribarren, José A. (Hospital de Donostia (Sant Sebastià, País Basc))
Escudero-Sánchez, Rosa (Instituto de Salud Carlos III)
del Toro López, María Dolores (Universidad de Sevilla)
Nodar, Andrés (Hospital Álvaro Cunqueiro (Vigo))
Sorlí, Luisa (Institut Hospital del Mar d'Investigacions Mèdiques)
Bahamonde, Alberto (Hospital Universitario del Bierzo)
Vilchez, Helem H. (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Gasch Blasi, Oriol (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Muñez, Elena (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Rodríguez-Montserrat, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
García-País, María José (Hospital Universitario Lucus Augusti (Lugo))
Haddad, Sleiman (Hospital Universitari Vall d'Hebron)
Sellarès-Nadal, Júlia (Hospital Universitari Vall d'Hebron)
Murillo Rubio, Oscar (Hospital Universitari de Bellvitge)
Rodriguez-Pardo, Dolors (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Fecha:	2023
Resumen:	Infection after spinal instrumentation (IASI) by Cutibacterium spp. is being more frequently reported. The aim of this study was to analyse the incidence, risk factors, clinical characteristics, and outcome of a Cutibacterium spp. IASI (CG) compared with non- Cutibacterium IASI (NCG) infections, with an additional focus on the role of rifampin in the treatment. All patients from a multicentre, retrospective, observational study with a confirmed IASI between January 2010 and December 2016 were divided into two groups: (CG and NCG) IASI. Baseline, medical, surgical, infection treatment, and follow-up data were compared for both groups. In total, 411 patients were included: 27 CG and 384 NCG. The CG patients were significantly younger. They had a longer median time to diagnosis (23 vs. 13 days) (p = 0. 025), although 55. 6% debuted within the first month after surgery. Cutibacterium patients were more likely to have the implant removed (29. 6% vs. 12. 8%; p = 0. 014) and received shorter antibiotic regimens (p = 0. 014). In 33% of Cutibacterium cases, rifampin was added to the baseline therapy. None of the 27 infections resulted in treatment failure during follow-up regardless of rifampin use. Cutibacterium spp. is associated with a younger age and may cause both early and late IASIs. In our experience, the use of rifampin to improve the outcome in the treatment of a Cutibacterium spp. IASI is not relevant since, in our series, none of the cases had therapeutic failure regardless of the use of rifampin.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Cutibacterium spp ; Rifampin ; Spine surgery ; Surgical site infection
Publicado en:	Antibiotics, Vol. 12 (march 2023) , ISSN 2079-6382

DOI: 10.3390/antibiotics12030518
PMID: 36978385

10 p, 282.3 KB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Instituto de Investigación e Innovación Parc Taulí (I3PT)
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