Dying in self-defence : a comparative overview of immunogenic cell death signalling in animals and plants
Maekawa, Takaki (CEPLAS Cluster of Excellence on Plant Sciences at the University of Cologne)
Kashkar, Hamid (University of Cologne. Cologne Excellence Cluster on Cellular Stress Responses in Aging-Associated Diseases (CECAD))
Sánchez Coll, Núria (Consejo Superior de Investigaciones Científicas (CSIC))

Data:	2022
Resum:	Host organisms utilise a range of genetically encoded cell death programmes in response to pathogen challenge. Host cell death can restrict pathogen proliferation by depleting their replicative niche and at the same time dying cells can alert neighbouring cells to prepare environmental conditions favouring future pathogen attacks. As expected, many pathogenic microbes have strategies to subvert host cell death to promote their virulence. The structural and lifestyle differences between animals and plants have been anticipated to shape very different host defence mechanisms. However, an emerging body of evidence indicates that several components of the host-pathogen interaction machinery are shared between the two major branches of eukaryotic life. Many proteins involved in cell death execution or cell death-associated immunity in plants and animals exert direct effects on endomembrane and loss of membrane integrity has been proposed to explain the potential immunogenicity of dying cells. In this review we aim to provide a comparative view on how cell death processes are linked to anti-microbial defence mechanisms in plants and animals and how pathogens interfere with these cell death programmes. In comparison to the several well-defined cell death programmes in animals, immunogenic cell death in plant defence is broadly defined as the hypersensitive response. Our comparative overview may help discerning whether specific types of immunogenic cell death exist in plants, and correspondingly, it may provide new hints for previously undiscovered cell death mechanism in animals.
Ajuts:	Ministerio de Ciencia e Innovación PID2019-108595RB-I00 Ministerio de Ciencia e Innovación CEX2019-000902-S
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Immune cell death ; Microbiology
Publicat a:	Cell Death and Differentiation, Vol. 30 (october 2022) , p. 258-268, ISSN 1476-5403

DOI: 10.1038/s41418-022-01060-6
PMID: 36195671

11 p, 2.2 MB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats