Risk Factors for COVID-19 in Inflammatory Bowel Disease : A National, ENEIDA-Based Case-Control Study (COVID-19-EII)
Zabana, Yamile (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Marín-Jiménez, Ignacio (Universidad Complutense de Madrid)
Rodríguez-Lago, Iago (Hospital Universitario de Galdakao)
Vera, Isabel (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Martín-Arranz, María Dolores (Hospital Universitario La Paz (Madrid))
Guerra, Iván (Hospital Universitario de Fuenlabrada ( Madrid))
P. Gisbert, Javier (Instituto de Investigación Sanitaria Princesa)
Mesonero, Francisco (Hospital Universitario Ramón y Cajal (Madrid))
Benítez-Leiva, Olga (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Taxonera, Carlos (Hospital Clínico San Carlos (Madrid))
Ponferrada Díaz, Ángel (Hospital Universitario Infanta Leonor)
Piqueras, Marta (Consorci Sanitari de Terrassa)
Lucendo, Alfredo J (Hospital General de Tomelloso)
Caballol, Berta (Hospital Clínic i Provincial de Barcelona)
Mañosa i Ciria, Míriam (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Martínez-Montiel, Pilar (Hospital Universitario 12 de Octubre (Madrid))
Bosca-Watts, Marta Maia (Hospital Clínic Universitari (València))
Gordillo, Jordi (Institut d'Investigació Biomèdica Sant Pau)
Bujanda, Luis (Hospital de Donostia (Sant Sebastià, País Basc))
Manceñido, Noemí (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Martínez-Pérez, Teresa (Hospital Virgen de La Luz (Cuenca))
López, Alicia (Hospital del Mar (Barcelona, Catalunya))
Rodríguez-Gutiérrez, Cristina (Complejo Hospitalario de Navarra)
García-López, Santiago (Hospital Universitario Miguel Servet (Saragossa))
Vega, Pablo (Complejo Hospitalario Universitario de Ourense)
Rivero, Montserrat (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Melcarne, Luigi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Calvo Iñiguez, María (Hospital San Pedro-Logroño)
Iborra, Marisa (Hospital Universitari i Politècnic La Fe (València))
Barreiro de-Acosta, Manuel (Hospital Clínico Universitario (Santiago de Compostela, Galícia))
Sicilia, Beatriz (Hospital Universitario de Burgos)
Barrio, Jesús (Hospital Universitario Río Hortega (Valladolid))
Pérez Calle, José Lázaro (Hospital Universitario Fundación Alcorcón)
Busquets, David (Hospital Universitari de Girona Doctor Josep Trueta)
Pérez-Martínez, Isabel (Hospital Universitario Central de Asturias)
Navarro-Llavat, Mercè (Hospital de Sant Joan Despí Moisès Broggi)
Hernández, Vicent (Hospital Álvaro Cunqueiro (Vigo))
Argüelles-Arias, Federico (Hospital Universitario Virgen Macarena (Sevilla, Andalusia))
Ramírez Esteso, Fernando (Hospital General Universitario de Ciudad Real)
Meijide, Susana (Hospital Universitario de Cruces (Barakaldo, País Basc))
Ramos, Laura (Hospital Universitario de Canarias (La Laguna))
Gomollón, Fernando (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Muñoz, Fernando (Hospital Universitario de Salamanca)
Suris, Gerard (Hospital Universitari de Bellvitge)
Ortiz de Zarate, Jone (Hospital de Basurto (Bilbao, Biscaia))
Huguet, José María (Hospital General Universitario de Valencia)
Llaó, Jordina (Althaia Xarxa Assistencial Universitària de Manresa)
García-Sepulcre, Mariana Fe (Hospital General Universitario de Elche)
Sierra Ausín, Mónica (Complejo Asistencial Universitario de León)
Durà, Miguel (Hospital Clínico Universitario de Valladolid)
Estrecha, Sandra (Hospital Universitario Álava)
Fuentes Coronel, Ana María (Hospital Virgen de la Concha (Zamora))
Hinojosa, Esther (Hospital de Manises (València))
Olivan, Lorenzo (Hospital Universitario San Jorge)
Iglesias, Eva (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Gutiérrez Casbas, Ana (Hospital General Universitario de Alicante (Alacant, País Valencià))
Varela, Pilar (Hospital Universitario de Cabueñes (Gijón))
Rull, Núria (Hospital Universitari Son Llàtzer (Palma de Mallorca, Balears))
Gilabert, Pau (Hospital de Viladecans)
Hernández Camba, Alejandro (Hospital Universitario Nuestra Señora de Candelaria (Santa Cruz de Tenerife))
Brotons, Alicia (Hospital Vega Baja de Orihuela)
Ginard, Daniel (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Sesé, Eva (Hospital Universitari Arnau de Vilanova)
Carpio, Daniel (Complejo Hospitalario Universitario de Pontevedra)
Aceituno, Montserrat (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Cabriada, José Luis (Hospital Universitario de Galdakao)
González-Lama, Yago (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Jiménez, Laura (Hospital Universitario de Fuenlabrada ( Madrid))
Chaparro, María (Instituto de Investigación Sanitaria Princesa)
López-San Román, Antonio (Hospital Universitario Ramón y Cajal (Madrid))
Alba, Cristina (Hospital Clínico San Carlos (Madrid))
Plaza-Santos, Rocío (Hospital Universitario Infanta Leonor)
Mena, Raquel (Consorci Sanitari de Terrassa)
Tamarit-Sebastián, Sonsoles (Hospital General de Tomelloso)
Ricart, Elena (Hospital Clínic i Provincial de Barcelona)
Calafat, Margalida (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Olivares, Sonsoles (Hospital Universitario 12 de Octubre (Madrid))
Navarro, Pablo (Hospital Clínic Universitari (València))
Bertoletti, Federico (Institut d'Investigació Biomèdica Sant Pau)
Alonso-Galán, Horacio (Hospital de Donostia (Sant Sebastià, País Basc))
Pajares, Ramón (Hospital Universitario Infanta Sofía (San Sebastián de los Reyes))
Olcina, Pablo (Hospital Virgen de La Luz (Cuenca))
Manzano, Pamela (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Domènech, Eugeni (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Esteve, Maria (Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	(1) Scant information is available concerning the characteristics that may favour the acquisition of COVID-19 in patients with inflammatory bowel disease (IBD). Therefore, the aim of this study was to assess these differences between infected and noninfected patients with IBD. (2) This nationwide case-control study evaluated patients with inflammatory bowel disease with COVID-19 (cases) and without COVID-19 (controls) during the period March-July 2020 included in the ENEIDA of GETECCU. (3) A total of 496 cases and 964 controls from 73 Spanish centres were included. No differences were found in the basal characteristics between cases and controls. Cases had higher comorbidity Charlson scores (24% vs. 19%; p = 0. 02) and occupational risk (28% vs. 10. 5%; p < 0. 0001) more frequently than did controls. Lockdown was the only protective measure against COVID-19 (50% vs. 70%; p < 0. 0001). No differences were found in the use of systemic steroids, immunosuppressants or biologics between cases and controls. Cases were more often treated with 5-aminosalicylates (42% vs. 34%; p = 0. 003). Having a moderate Charlson score (OR: 2. 7; 95%CI: 1. 3-5. 9), occupational risk (OR: 2. 9; 95%CI: 1. 8-4. 4) and the use of 5-aminosalicylates (OR: 1. 7; 95%CI: 1. 2-2. 5) were factors for COVID-19. The strict lockdown was the only protective factor (OR: 0. 1; 95%CI: 0. 09-0. 2). (4) Comorbidities and occupational exposure are the most relevant factors for COVID-19 in patients with IBD. The risk of COVID-19 seems not to be increased by immunosuppressants or biologics, with a potential effect of 5-aminosalicylates, which should be investigated further and interpreted with caution.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	COVID-19 ; SARS-CoV-2 ; Inflammatory bowel disease ; 5-aminosalicylates ; Immunosuppression
Published in:	Journal of clinical medicine, Vol. 11 (december 2022) , ISSN 2077-0383

DOI: 10.3390/jcm11247540
PMID: 36556155

14 p, 618.6 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles