Erythrocyte Membrane Docosahexaenoic Acid (DHA) and Lipid Profile in Preterm Infants at Birth and Over the First Month of Life : A Comparative Study with Infants at Term
Castillo Salinas, Félix (Universitat Autònoma de Barcelona)
Montaner Ramón, Alicia (Universitat Autònoma de Barcelona)
Castillo-Ferrer, Félix-Joel (Hospital Universitari Vall d'Hebron)
Domingo-Carnice, Adrià (Hospital Universitari de Bellvitge)
Cordobilla, Begoña (Universitat de Barcelona)
Domingo, Joan Carles (Universitat de Barcelona)

Data:	2022
Resum:	An observational comparative study was designed to assess the fatty acids profile in erythrocyte membrane phospholipids of 30 preterm neonates (<32 weeks gestation) at birth and after 1 month of life versus a convenience sample of 10 infants born at term. The panel of fatty acids included the families and components of saturated fatty acids (SFAs), monounsaturated fatty acids (MUFAs), and n-6 and n-3 polyunsaturated fatty acids (PUFAs) as well as enzyme activity indexes and fatty acids ratios. At birth, the comparison of fatty acid families between preterm and term neonates showed a significantly higher content of SFAs and n-6 PUFAs, and a significantly lower content of MUFAs and n-3 PUFAs in the preterm group. After 30 days of life, significantly higher levels of n-6 PUFAs and significantly lower levels of n-3 PUFAs among preterm neonates persisted. At 30 days of birth, n-6 PUFA/n-3 PUFA and arachidonic acid (ARA) ARA/DHA remained significantly elevated, and DHA sufficiency index significantly decreased in the preterm group. The pattern of n-3 PUFA deficiency at birth and sustained for the first month of life would support the need of milk banking fortified with DHA and the use of DHA supplementation in breastfeeding mothers.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Docosahexaenoic acid ; Arachidonic acid ; Linoleic acid ; Eicosapentaenoic acid ; Lipid profile ; Preterm infants ; Erythrocyte membrane
Publicat a:	Nutrients, Vol. 14, Num. 23 (November 2022) , art. 4956, ISSN 2072-6643

DOI: 10.3390/nu14234956
PMID: 36500985

13 p, 1.6 MB

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