Protein Supplementation with Short Peptides Prevents Early Muscle Mass Loss after Roux-en-Y-Gastric Bypass
Comas Martínez, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fidilio, Enzamaria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Palmas Candia, Fiorella (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cordero-Vazquez, Efrain (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Hernández, Irene (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vilallonga, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Burgos Peláez, Rosa (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vila-Martí, Anna (Universitat de Vic - Universitat Central de Catalunya)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ciudin, Andreea (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	A significant reduction in fat-free mass (FFM) following bariatric surgery (BS) has been reported, and adequate protein intake is recommended for FFM preservation. Current guidelines of nutritional management after BS recommend complex protein (CP) compounds. However, Roux-en-Y-gastric bypass (RYGB) has a negative impact on CP digestion, leading to protein malabsorption. At present, there is no data regarding the impact of early supplementation with short peptide-based (SPB) or hydroxy methylbutyrate (HMB)-enriched formulas on the evolution of the FFM after the BS. Aim: The aim of this study is to evaluate the effect of nutritional products based on CP, HBM-enriched, or SPB formulas on the FFM of patients that undergo RYGB. Material and methods: This is a prospective interventional study, including three groups of patients (according to the type of protein product) as candidates for BS, recruited between December 2021 and April 2022, matched by age, gender, and BMI. All patients underwent evaluations at baseline and one month post-BS, including: medical history, physical and anthropometric evaluation, bioimpedance, and biochemical analysis. Results: A total of 60 patients were recruited: 63% women, mean age 43. 13 ± 9. 4 years, and BMI 43. 57 ± 4. 1 kg/m 2. The % of FFM loss from total weight loss (TWL) was significantly lower in the SPB group than CP and HMB groups despite the major %TWL in this group (40. 60 ± 17. 27 in CP, 34. 57 ± 13. 15 in HMB, and 19. 14 ± 9. 38 in SPB, p < 0. 001). TWL% was 9. 98 ± 1. 82 vs. 9. 83 ± 2. 71 vs. 13. 56 ± 4. 30, p < 0. 001, respectively. Conclusion: In our study, the SPB supplementation prevented almost 50% FFM lost from the TWL than the CP- or HMB-enriched compounds at one month post-BS. These results are significant in the setting of muscle mass preservation after the BS, and have the potential to change the current guidelines for the management of nutritional supplementation after BS.
Ajuts:	Instituto de Salud Carlos III PI20/01086
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Bariatric surgery ; Complex protein ; Fat-free mass ; HMB-enriched formulas ; Nutrition supplementation ; Protein ; Short peptides
Publicat a:	Nutrients, Vol. 14 (december 2022) , ISSN 2072-6643

DOI: 10.3390/nu14235095
PMID: 36501125

9 p, 300.4 KB

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