Epigenome-Wide Association Study in Peripheral Tissues Highlights DNA Methylation Profiles Associated with Episodic Memory Performance in Humans
Sommerer, Yasmine (University of Lübeck)
Dobricic, Valerija (University of Lübeck)
Schilling, Marcel (University of Lübeck)
Ohlei, Olena (University of Lübeck)
Bartrés-Faz, David (Campus Clínic August Pi i Sunyer)
Cattaneo, Gabriele (Institut Germans Trias i Pujol. Institut Guttmann)
Demuth, Ilja (Charité - Universitätsmedizin Berlin)
Düzel, Sandra (Max Planck Institute for Human Development)
Franzenburg, Sören (Christian-Albrechts-University of Kiel)
Fuß, Janina (Christian-Albrechts-University of Kiel)
Lindenberger, Ulman (Max Planck Institute for Human Development)
Pascual Leone, Álvaro (Harvard Medical School)
Sabet, Sanaz Sedghpour (Christian-Albrechts-University of Kiel)
Solé-Padullés, Cristina (Campus Clínic August Pi i Sunyer)
Tormos, Josep M. (Institut Germans Trias i Pujol. Institut Guttmann)
Vetter, Valentin Max (Charité - Universitätsmedizin Berlin)
Wesse, Tanja (Christian-Albrechts-University of Kiel)
Franke, Andre (Christian-Albrechts-University of Kiel)
Lill, Christina M. (Imperial College London)
Bertram, Lars (University of Oslo)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	The decline in episodic memory (EM) performance is a hallmark of cognitive aging and an early clinical sign in Alzheimer's disease (AD). In this study, we conducted an epigenome-wide association study (EWAS) using DNA methylation (DNAm) profiles from buccal and blood samples for cross-sectional (n = 1019) and longitudinal changes in EM performance (n = 626; average follow-up time 5. 4 years) collected under the auspices of the Lifebrain consortium project. The mean age of participants with cross-sectional data was 69 ± 11 years (30-90 years), with 50% being females. We identified 21 loci showing suggestive evidence of association (p < 1 × 10 −5) with either or both EM phenotypes. Among these were SNCA, SEPW1 (both cross-sectional EM), ITPK1 (longitudinal EM), and APBA2 (both EM traits), which have been linked to AD or Parkinson's disease (PD) in previous work. While the EM phenotypes were nominally significantly (p < 0. 05) associated with poly-epigenetic scores (PESs) using EWASs on general cognitive function, none remained significant after correction for multiple testing. Likewise, estimating the degree of "epigenetic age acceleration" did not reveal significant associations with either of the two tested EM phenotypes. In summary, our study highlights several interesting candidate loci in which differential DNAm patterns in peripheral tissue are associated with EM performance in humans.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	CpG ; Cross-sectional ; DNA methylation ; Epigenome-wide association study ; Episodic memory ; EWAS ; Longitudinal
Publicat a:	Biomedicines, Vol. 10 (november 2022) , ISSN 2227-9059

DOI: 10.3390/biomedicines10112798
PMID: 36359320

16 p, 1.6 MB

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