SARS-CoV-2 Vaccination Coverage and Factors Associated with Low Uptake in a Cohort of People Living with HIV
Nomah, Daniel Kwakye (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Llibre, Josep M. (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Díaz, Yesika (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Moreno-Fornés, Sergio (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Aceitón, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bruguera Riera, Andreu (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Gutiérrez-Macià, Maria (Institut d'Investigació Biomèdica Sant Pau)
Imaz, Arkaitz (Hospital Universitari de Bellvitge)
Suanzes, Paula (Hospital Universitari Vall d'Hebron)
Navarro, Gemma (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Orti, Amat (Hospital de Tortosa)
Miró, José M (Hospital Clínic i Provincial de Barcelona)
Casabona-Barbarà, Jordi (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Reyes-Urueña, Juliana (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	People living with HIV (PLWH) are prioritised for SARS-CoV-2 vaccination due to their vulnerability to severe COVID-19. Therefore, the epidemiological surveillance of vaccination coverage and the timely identification of suboptimally vaccinated PLWH is vital. We assessed SARS-CoV-2 vaccination coverage and factors associated with under-vaccination among PLWH in Catalonia, Spain. As of 11. 12. 2021, 9945/14942 PLWH (66. 6%) had received ≥1 dose of a SARS-CoV-2 vaccine. Non-Spanish origin (adjusted odds ratio (aOR) 0. 64, 95% CI 0. 59-0. 70), CD4 count of 200-349 cells/μL (aOR 0. 74, 95% CI 0. 64-0. 86) or 350-499 cells/μL (aOR 0. 79, 95% CI 0. 70-0. 88), detectable plasma HIV-RNA (aOR 0. 61 95% CI 0. 53-0. 70), and previous SARS-CoV-2 diagnosis (aOR 0. 58 95% CI 0. 51-0. 65) were associated with under-vaccination. SARS-CoV-2 diagnosis (437 [9. 5%] vs. 323 [3. 5%], p < 0. 001), associated hospitalisations (10 [2. 3%] vs. 0 [0%], p < 0. 001), intensive care unit admissions (6 [1. 4%] vs. 0 [0%], p < 0. 001), and deaths (10 [2. 3%] vs. 0 [0%], p < 0. 001) were higher among unvaccinated PLWH. Vaccination coverage was lower among PLWH with a CD4 count >200 cells/μL, detectable plasma HIV-RNA, previous SARS-CoV-2 diagnosis, and migrants. SARS-CoV-2 diagnosis, associated hospitalisations, and deaths among PLWH were lower among the vaccinated compared with the unvaccinated. SARS-CoV-2 vaccination prioritisation has not completely reached vulnerable PLWH with poorer prognosis. This information can be used to inform public health strategies.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Coronavirus disease 2019 (COVID-19) ; HIV ; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ; Vaccination ; Vaccine effectiveness
Published in:	Microorganisms, Vol. 10 (august 2022) , ISSN 2076-2607

DOI: 10.3390/microorganisms10081666
PMID: 36014083

12 p, 632.4 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Institut de Recerca Sant Pau
Articles > Research articles
Articles > Published articles