Home > Articles > Published articles > Cortical microstructure in primary progressive aphasia : |
Date: | 2022 |
Abstract: | Background: Cortical mean diffusivity is a novel imaging metric sensitive to early changes in neurodegenerative syndromes. Higher cortical mean diffusivity values reflect microstructural disorganization and have been proposed as a sensitive biomarker that might antedate macroscopic cortical changes. We aimed to test the hypothesis that cortical mean diffusivity is more sensitive than cortical thickness to detect cortical changes in primary progressive aphasia (PPA). Methods: In this multicenter, case-control study, we recruited 120 patients with PPA (52 non-fluent, 31 semantic, and 32 logopenic variants; and 5 GRN-related PPA) as well as 89 controls from three centers. The 3-Tesla MRI protocol included structural and diffusion-weighted sequences. Disease severity was assessed with the Clinical Dementia Rating scale. Cortical thickness and cortical mean diffusivity were computed using a surface-based approach. Results: The comparison between each PPA variant and controls revealed cortical mean diffusivity increases and cortical thinning in overlapping regions, reflecting the canonical loci of neurodegeneration of each variant. Importantly, cortical mean diffusivity increases also expanded to other PPA-related areas and correlated with disease severity in all PPA groups. Cortical mean diffusivity was also increased in patients with very mild PPA when only minimal cortical thinning was observed and showed a good correlation with measures of disease severity. Conclusions: Cortical mean diffusivity shows promise as a sensitive biomarker for the study of the neurodegeneration-related microstructural changes in PPA. |
Grants: | Instituto de Salud Carlos III JR20/0018 Instituto de Salud Carlos III FI18/00275 Instituto de Salud Carlos III CP20/00038 Instituto de Salud Carlos III PI14/01126 Instituto de Salud Carlos III PI17/01019 Instituto de Salud Carlos III PI13/01532 Instituto de Salud Carlos III PI16/01825 Instituto de Salud Carlos III PI18/00335 Instituto de Salud Carlos III INT19/00016 Instituto de Salud Carlos III PI18/00435 Instituto de Salud Carlos III PI15/01618 Instituto de Salud Carlos III PI20/00448 Instituto de Salud Carlos III PI17/01896 Instituto de Salud Carlos III PI20/01330 Instituto de Salud Carlos III AC19:00103 Agència de Gestió d'Ajuts Universitaris i de Recerca PERIS SLT002/16/00408 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014SGR-0235 Agència de Gestió d'Ajuts Universitaris i de Recerca PERIS SLT006/17/125 Agència de Gestió d'Ajuts Universitaris i de Recerca PERIS SLT006/17/00119 European Commission. Horizon 2020 H2020-SC1-BHC-2018-2020/GA 965422 |
Note: | Altres ajuts: Global Brain Health Institute (GBHI), Alzheimer's Association, and Alzheimer's Society (GBHI ALZ UK-21-720973); Hospital Clínic de Barcelona (Emili Letang post-residency research grant); Ministerio de Ciencia, Innovación y Universidades; Association for Frontotemporal Degeneration (Clinical Research Postdoctoral Fellowship, AFTD 2019-2021); NIH grants (AG019724, AG032306, AG045390, NS092089, AG045333, AG056749, AG062422, P30AG062422, P01AG019724); National Institutes of Health (NIA grants 1R01AG056850-01A1, R21AG056974, R01AG061566); CIBERNED program (Program 1, Alzheimer Disease); Fondo Europeo de Desarrollo Regional (FEDER), Unión Europea, una manera de hacer Europa; La "Marató de TV3" (20141210, 044412, 20143810); Generalitat de Catalunya; BBVA foundation; Fundació Bancaria La Caixa; Sage Pharma (HCB2020/1483). |
Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Language: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Subject: | Difusion ; Magnetic resonance ; Primary progressive aphasia ; Alzheimer's disease ; Frontotemporal lobar degeneration |
Published in: | Alzheimer's research & therapy, Vol. 14 Núm. 1 (december 2022) , p. 27, ISSN 1758-9193 |
13 p, 3.8 MB |