Vitamin D3 Supplementation in Overweight/Obese Pregnant Women : No Effects on the Maternal or Fetal Lipid Profile and Body Fat Distribution-A Secondary Analysis of the Multicentric, Randomized, Controlled Vitamin D and Lifestyle for Gestational Diabetes Prevention Trial (DALI)
Harreiter, Jürgen (Medical University of Vienna)
Mendoza, Lilian Cristina (Institut d'Investigació Biomèdica Sant Pau)
Simmons, David (Western Sydney University. Macarthur Clinical School)
Desoye, Gernot (Medical University of Graz)
Devlieger, Roland (Department of Obstetrics. Gynecology and Fertility. GZA Sint-Augustinus)
Galjaard, Sander (University Medical Centre Rotterdam. Department of Obstetrics and Gynaecology)
Damm, Peter (University of Copenhagen. Department of Clinical Medicine)
Mathiesen, Elisabeth R. (University of Copenhagen. Department of Clinical Medicine)
Jensen, Dorte M (University of Southern Denmark. Department of Clinical Research)
Andersen, Lise-Lotte (University of Southern Denmark. Department of Clinical Research)
Dunne, Fidelma (Clinical Research Facility (CRF) and National University of Ireland)
Lapolla, Annunziata (Department of Medicine. Universita Degli Studi di Padova)
Dalfra, Maria Grazia (Department of Medicine. Universita Degli Studi di Padova)
Bertolotto, Alessandra (Azienda Ospedaliero-Universitaria Pisana)
Wender-Ozegowska, Ewa (Poznan University of Medical Sciences)
Zawiejska, Agnieszka (Poznan University of Medical Sciences)
Hill, David J. (Lawson Health Research Institute)
Jelsma, Judith G. M (Amsterdam Public Health Research Institute)
Snoek, Frank J. (Amsterdam Public Health Research Institute)
Worda, Christof (Medical University of Vienna)
Bancher-Todesca, Dagmar (Medical University of Vienna)
van Poppel, M.N.M. (University of Graz. Institute of Human Movement Science)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Kautzky-Willer, Alexandra (Gender Institute)

Data:	2022
Resum:	Vitamin D deficiency is a common finding in overweight/obese pregnant women and is associated with increased risk for adverse pregnancy outcome. Both maternal vitamin D deficiency and maternal obesity contribute to metabolic derangements in pregnancy. We aimed to assess the effects of vitamin D3 supplementation in pregnancy versus placebo on maternal and fetal lipids. Main inclusion criteria were: women <20 weeks' gestation, BMI ≥ 29 kg/m. Eligible women (n = 154) were randomized to receive vitamin D3 (1600 IU/day) or placebo. Assessments were performed <20, 24-28 and 35-37 weeks and at birth. Linear regression models were used to assess effects of vitamin D on maternal and cord blood lipids. In the vitamin D group significantly higher total 25-OHD and 25-OHD3 levels were found in maternal and cord blood compared with placebo. Adjusted regression models did not reveal any differences in triglycerides, LDL-C, HDL-C, free fatty acids, ketone bodies or leptin between groups. Neonatal sum of skinfolds was comparable between the two groups, but correlated positively with cord blood 25-OH-D3 (r = 0. 34, p = 0. 012). Vitamin D supplementation in pregnancy increases maternal and cord blood vitamin D significantly resulting in high rates of vitamin D sufficiency. Maternal and cord blood lipid parameters were unaffected by Vitamin D3 supplementation.
Ajuts:	European Commission 242187
Nota:	Altres ajuts: Netherlands Organization for Health Research and Development (ZonMw) (200310013); Polish Ministry of Science (2203/7, PR/2011/2); Odense University Free Research Fund; NIHR Clinical Research Network: Eastern; Spain (CAIBER 1527-B-226).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Vitamin D ; Lipids ; Triglycerides ; Cholesterol ; Free fatty acids ; Overweight ; Obesity pregnancy ; Pregnancy outcomes ; Birth outcomes ; Cord blood ; Skinfolds ; Body fat distribution
Publicat a:	Nutrients, Vol. 14 Núm. 18 (september 2022) , p. 3781, ISSN 2072-6643

DOI: 10.3390/nu14183781
PMID: 36145157

15 p, 671.9 KB

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