Epidemiological Characteristics and Spatio-Temporal Distribution of Hepatitis A in Spain in the Context of the 2016/2017 European Outbreak
Guerrero-Vadillo, María (Centro Nacional de Epidemiología (Espanya))
Peñuelas, Marina (Centro Nacional de Epidemiología (Espanya))
Domínguez, Ángela (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Godoy, Pere (Institut de Recerca Biomèdica de Lleida)
Gómez-Barroso, Diana (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Soldevila, Nuria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Izquierdo, Conchita (Agència de Salut Pública de Catalunya)
Martínez, Ana (Agència de Salut Pública de Catalunya)
Torner, Nuria (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)
Avellón, Ana (Unidad de Hepatitis. Centro Nacional de Microbiología. Instituto de Salud Carlos III)
Rius i Gibert, Maria Cristina (Agència de Salut Pública de Barcelona)
Varela, Carmen (Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública)

Data:	2022
Resum:	The aim of our study was to describe the results of the epidemiological surveillance of hepatitis A infections in Spain in the context of the 2016/2017 European outbreak, particularly of hepatitis A outbreaks reported in the MSM population, incorporating the results of a spatio-temporal analysis of cases. Hepatitis A cases and outbreaks reported in 2016-2017 to the National Epidemiological Surveillance Network were reviewed: outbreaks in which some of the cases belonged to the MSM group were described, and clusters of hepatitis A cases in men and women were analysed using a space-time scan statistic. Twenty-six outbreaks were identified, with a median size of two cases per outbreak, with most of the outbreak-related cases belonging to the 15-44 years-old group. Nearly 85% occurred in a household setting, and in all outbreaks, the mode of transmission was direct person-to-person contact. Regarding space-time analysis, twenty statistically significant clusters were identified in the male population and eight in the female population; clusters in men presented a higher number of observed cases and affected municipalities, as well as a higher percentage of municipalities classified as large urban areas. The elevated number of cases detected in clusters of men indicates that the number of MSM-related outbreaks may be higher than reported, showing that spatio-temporal analysis is a complementary, useful tool which may improve the detection of outbreaks in settings where epidemiological investigation may be more challenging.
Nota:	Altres ajuts: The APC was funded by the Programme of Prevention, Surveillance, and Control of Transmissible Diseases (PREVICET), CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, Madrid (Spain).
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Hepatitis A virus ; Epidemiological surveillance ; MSM ; Outbreaks ; Space-time clustering ; Urban population
Publicat a:	International journal of environmental research and public health, Vol. 19 Núm. 24 (december 2022) , p. 16775, ISSN 1660-4601

DOI: 10.3390/ijerph192416775
PMID: 36554666

13 p, 2.7 MB

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