Clinical Profiles and Patterns of Kidney Disease Progression in C3 Glomerulopathy
Caravaca-Fontan, Fernando (Universidad Complutense de Madrid)
Cavero Escribano, Teresa (Hospital 12 de Octubre (Madrid))
Díaz Encarnación, Montserrat Mercedes (Fundació Puigvert)
Cabello, Virginia (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron)
Quintana, Luis F (Hospital Clínic i Provincial de Barcelona)
Marco Rusiñol, Helena (Fundació Puigvert)
Barros, Xoana (Hospital Universitari de Girona Doctor Josep Trueta)
Ramos Terrades, Natalia (Hospital Universitari Vall d'Hebron)
Rodríguez-Mendiola, Nuria (Hospital Universitario Ramón y Cajal (Madrid))
Cruz, Sonia (Hospital Universitario Juan Ramón Jiménez)
Fernández-Juárez, Gema (Hospital Universitario La Paz (Madrid))
Rodríguez, Adela (Hospital Universitario Virgen del Rocío (Sevilla, Andalusia))
Pérez de José, Ana (Hospital General Universitario Gregorio Marañón)
Rabasco, Cristina (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Rodado, Raquel (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Fernández, Loreto (Complejo Hospitalario de Navarra)
Pérez-Gómez, Vanessa (Hospital Universitario Fundación Jiménez Díaz)
Ávila, Ana (Hospital Universitari Doctor Peset (València))
Bravo, Luis (Complejo Hospitalario Universitario de A Coruña)
Espinosa, Natalia (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Allende, Natalia (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Sanchez de la Nieta, Maria Dolores (Hospital General Universitario de Ciudad Real)
Rodríguez García, Eva (Hospital del Mar (Barcelona, Catalunya))
Rivas, Begoña (Hospital Universitario La Paz (Madrid))
Melgosa, Marta (Hospital Universitario La Paz (Madrid))
Huerta, Ana (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Miquel, Rosa (Hospital Universitario Canarias)
Mon, Carmen (Hospital Universitario Severo Ochoa)
Fraga Rodríguez, Gloria María (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
De Lorenzo, Alberto (Hospital Universitario de Getafe (Madrid))
Draibe, Juliana (Hospital Universitari de Bellvitge)
González, Fayna (Hospital Universitario de Gran Canaria Dr. Negrín)
Shabaka, Amir (Hospital Universitario Clínico San Carlos (Madrid))
López-Rubio, Maria Esperanza (Complejo Hospitalario Universitario de Albacete)
Fenollosa, María Ángeles (Consorci Hospitalari Provincial de Castelló)
Martín-Penagos, Luis (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Da Silva, Iara (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Titos, Juana Alonso (Hospital Regional Universitario Carlos Haya (Málaga))
Rodríguez de Córdoba, Santiago (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Goicoechea de Jorge, Elena (Universidad Complutense de Madrid)
Praga, Manuel (Hospital 12 de Octubre (Madrid))
Universitat Autònoma de Barcelona

Data:	2023
Resum:	C3 glomerulopathy is a rare kidney disease, which makes it difficult to collect large cohorts of patients to better understand its variability. The aims of this study were to describe the clinical profiles and patterns of progression of kidney disease. This was a retrospective, observational cohort study. Patients diagnosed with C3 glomerulopathy between 1995 and 2020 were enrolled. Study population was divided into clinical profiles by combining the following predictors: eGFR under/above 30 ml/min per 1. 73 m 2, proteinuria under/above 3. 5 g/d, and histologic chronicity score under/above 4. The change in eGFR and proteinuria over time was evaluated in a subgroup with consecutive measurements of eGFR and proteinuria. One hundred and fifteen patients with a median age of 30 years (interquartile range 19-50) were included. Patients were divided into eight clinical profiles. Kidney survival was significantly higher in patients with a chronicity score <4 and proteinuria <3. 5 g/d, both in those presenting with an eGFR under/above 30 ml/min per 1. 73 m 2. The median eGFR slope of patients who reached kidney failure was −6. 5 ml/min per 1. 73 m 2 per year (interquartile range −1. 6 to −17). Patients who showed a reduction in proteinuria over time did not reach kidney failure. On the basis of the rate of eGFR decline, patients were classified as faster eGFR decline (≥5 ml/min per 1. 73 m 2 per year), slower (<5 ml/min per 1. 73 m 2 per year), and those without decline. A faster eGFR decline was associated with higher probability of kidney failure. Kidney survival is significantly higher in patients with a chronicity score <4 and proteinuria <3. 5 g/d regardless of baseline eGFR, and a faster rate of decline in eGFR is associated with higher probability of kidney failure.
Ajuts:	Ministerio de Economía y Competitividad PI16/01685 Ministerio de Economía y Competitividad RD12/0021/0029 Agencia Estatal de Investigación PID2019-104912RB-I00
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Chronic kidney disease ; Complement ; Glomerulonephritis
Publicat a:	Kidney360, Vol. 4 (march 2023) , p. 659-672, ISSN 2641-7650

DOI: 10.34067/KID.0000000000000115
PMID: 36996481

14 p, 1.6 MB

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Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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