Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents
Violatto, Martina B. (Istituto di Ricerche Farmacologiche Mario Negri IRCCS)
Sitia, Giovanni (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Talamini, Laura (Istituto di Ricerche Farmacologiche Mario Negri IRCCS)
Morelli, Annalisa (Istituto di Ricerche Farmacologiche Mario Negri IRCCS)
Tran, Ngoc Lan (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Zhang, Qian (Shanghai Jiao Tong University)
Masood, Atif (Karachi Institute of Radiotherapy and Nuclear Medicine)
Pelaz, Beatriz (Universidade de Santiago de Compostela. Departamento de Química Inorgánica)
Chakraborty, Indranath (Indian Institute of Technology Kharagpur)
Cui, Daxiang (Shanghai Jiao Tong University)
Parak, Wolfgang J. (Universität Hamburg)
Salmona, Mario (Istituto di Ricerche Farmacologiche Mario Negri IRCCS)
Bastús, Neus G (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Puntes, Víctor (Institut Català de Nanociència i Nanotecnologia)
Bigini, Paolo (Istituto di Ricerche Farmacologiche Mario Negri IRCCS)

Fecha:	2023
Resumen:	Titanium dioxide nanoparticles (TiO NPs) are one of the main sources of the nanoparticulate matter exposure to humans. Although several studies have demonstrated their potential toxic effects, the real nature of the correlation between NP properties and their interaction with biological targets is still far from being fully elucidated. Here, engineered TiO NPs with various geometries (bipyramids, plates, and rods) have been prepared, characterized and intravenously administered in healthy mice. Parameters such as biodistribution, accumulation, and toxicity have been assessed in the lungs and liver. Our data show that the organ accumulation of TiO NPs, measured by ICP-MS, is quite low, and this is only partially and transiently affected by the NP geometries. The long-lasting permanence is exclusively restricted to the lungs. Here, bipyramids and plates show a higher accumulation, and interestingly, rod-shaped NPs are the most toxic, leading to histopathological pulmonary alterations. In addition, they are also able to induce a transient increase in serum markers related to hepatocellular injury. These results indicate that rods, more than bipyramidal and spherical geometries, lead to a stronger and more severe biological effect. Overall, small physico-chemical differences can dramatically modify both accumulation and safety.
Ayudas:	Agencia Estatal de Investigación PID2019-111218RB-I00 Agencia Estatal de Investigación RYC-2017-23457 Ministerio de Ciencia, Innovación y Universidades RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Titanium dioxide nanomaterial ; Physico-chemical properties ; Biodistribution ; Nanotoxicity
Publicado en:	Nanomaterials, Vol. 13, Issue 7 (April 2023) , art. 1174, ISSN 2079-4991

DOI: 10.3390/nano13071174
PMID: 37049267

19 p, 9.0 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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