The development of highly dense highly protected surfactant ionizable lipid RNA loaded nanoparticles
González-Rioja, Ramon (Institut Català de Nanociència i Nanotecnologia)
Salazar Montoya, Vivian Angélica (Institut Català de Nanociència i Nanotecnologia)
Bastús, Neus G (Institut Català de Nanociència i Nanotecnologia)
Puntes, Víctor (Hospital Universitari Vall d'Hebron. Institut de Recerca)

Fecha:	2023
Resumen:	The long quest for efficient drug administration has been looking for a universal carrier that can precisely transport traditional drugs, new genomic and proteic therapeutic agents. Today, researchers have found conditions to overcome the two main drug delivery dilemmas. On the one side, the versatility of the vehicle to efficiently load, protect and transport the drug and then release it at the target place. On the other hand, the questions related to the degree of PEGylation which are needed to avoid nanoparticle (NP) aggregation and opsonization while preventing cellular uptake. The development of different kinds of lipidic drug delivery vehicles and particles has resulted in the development of ionizable lipid nanoparticles (iLNPs), which can overcome most of the typical drug delivery problems. Proof of their success is the late approval and massive administration as the prophylactic vaccine for SARS-CoV-2. These ILNPs are built by electrostatic aggregation of surfactants, the therapeutic agent, and lipids that self-segregate from an aqueous solution, forming nanoparticles stabilized with lipid polymers, such as PEG. These vehicles overcome previous limitations such as low loading and high toxicity, likely thanks to low charge at the working pH and reduced size, and their entry into the cells via endocytosis rather than membrane perforation or fusion, always associated with higher toxicity. We herein revise their primary features, synthetic methods to prepare and characterize them, pharmacokinetic (administration, distribution, metabolization and excretion) aspects, and biodistribution and fate. Owing to their advantages, iLNPs are potential drug delivery systems to improve the management of various diseases and widely available for clinical use.
Ayudas:	Agencia Estatal de Investigación RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1431 Ministerio de Economía y Competitividad SEV-2017-0706
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Ionizable lipid nanoparticles ; RNA-loading ; Drug delivery carriers ; Pharmacokinetics ; Biodistribution and clearance
Publicado en:	Frontiers in immunology, Vol. 14 (February 2023) , art. 1129296, ISSN 1664-3224

DOI: 10.3389/fimmu.2023.1129296
PMID: 36923400

13 p, 1.6 MB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias > Institut Català de Nanociència i Nanotecnologia (ICN2)
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