Safety and effectiveness of ferric carboxymaltose intravenous therapy in pediatric patients with chronic kidney disease
Garcia-Ortega, Patricia (Hospital Universitari Vall d'Hebron)
Jimenez-Lozano, Ines (Hospital Universitari Vall d'Hebron)
Cruz, Alejandro (Hospital Universitari Vall d'Hebron)
Polo, Aurora Fernandez (Hospital Universitari Vall d'Hebron)
Lopez, Mercedes (Hospital Universitari Vall d'Hebron)
Ariceta Iraola, Gema (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Iron-deficiency anemia is the most common reason for worsening of the anemia characteristically seen in chronic kidney disease (CKD). Ferric carboxymaltose (FCM) is a macromolecular hydroxide ferric carbohydrate complex that allows high-dose iron to be administered parenterally for gradual, controlled release. The aim of this study was to retrospectively evaluate the safety and effectiveness of FCM treatment in pediatric patients with CKD non-dependent of hemodialysis, seen at a tertiary hospital. Data were collected on demographics, dosage, infusion time, laboratory results, and tolerability of the medicinal product. A total of 79 patients (40. 5% girls) were included; the median age [25th percentile (P25) to 75th percentile (P75)] was 9 years (5-13). Laboratory results at 15-45 days post-infusion revealed a median increase of 1. 4 g/dL (0. 9-1. 9) in hemoglobin, 224 μg/L (136-378. 5) in ferritin, 37 μg/dL (17. 5-71) in serum iron, and 18% (9. 3-27. 8) in transferrin saturation. All patients tolerated FCM infusions well, and no serious hypersensitivity reactions or anaphylactic reactions were observed. Only one adverse event was identified: drug extravasation at the end of the infusion in a 16-year-old patient. These data provide further evidence for the use of FCM as a safe and effective therapeutic option in pediatric patients with CKD, based on the low incidence of adverse effects, minor intervention required, and anemia improvement based on laboratory results.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Anemia ; Ferric carboxymaltose ; Intravenous iron ; Iron deficiency ; Kidney disease ; Pediatrics
Publicat a:	Frontiers in Pediatrics, Vol. 10 (october 2022) , ISSN 2296-2360

DOI: 10.3389/fped.2022.967233
PMID: 36275063

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