Complementary pre-screening strategies to uncover hidden prodromal and mild Alzheimer's disease : Results from the MOPEAD project
Boada, Mercè (Universitat Internacional de Catalunya)
Rodrigo, Adrián (GMV SECURE E SOLUTIONS)
Jessen, Frank (Faculty of Medicine and University Hospital Cologne)
Wimblad, Bengt (Karolinska Univ Hospital)
Kramberger, Milica G. (Univerza V Ljubljani)
Visser, Pieter Jelle (Maastricht University)
Simó Canonge, Rafael (Hospital Universitari Vall d'Hebron)
Rodríguez-Gomez, Octavio (Universitat Internacional de Catalunya)
Ciudin, Andreea (Hospital Universitari Vall d'Hebron)
Georges, Jean (Alzheimer Europe)
Dumas, Annete (ASDM Consulting)
Maguire, Peggy (European Institute of Women's Health)
Krivec, David (Zdruzenje Spomincica)
Wimo, Anders (Karolinska Institutet (Estocolm, Suècia))
Valero, Sergi (Instituto de Salud Carlos III)
Alegret, Montserrat (Instituto de Salud Carlos III)
Jamilis, Laura (GMV SECURE E SOLUTIONS)
Zwan, Marissa (Vrije Universiteit Amsterdam)
Sannemann, Lena (Faculty of Medicine and University Hospital Cologne)
Arrufat, Jordi (EAP Sarrià-Vallvidrera-Les Planes)
Stomrud, Erik (Region Kalmar County)
Johansson, Gunilla (Karolinska Institutet (Estocolm, Suècia))
Glaysher, Bridget (Modus Research and Innovation Limited)
Stewart, Neil (Modus Research and Innovation Limited)
Belger, Mark (Eli Lilly and Company (Lilly UK))
Iradier, Fatima (Eli Lilly and Company)
Campo, Laura (Eli Lilly and Company)
Universitat Autònoma de Barcelona

Data:	2021
Resum:	The Models of Patient Engagement for Alzheimer's Disease (MOPEAD) project was conceived to explore innovative complementary strategies to uncover hidden prodromal and mild Alzheimer's disease (AD) dementia cases and to raise awareness both in the general public and among health professionals about the importance of early diagnosis. Four different strategies or RUNs were used: (a) a web-based (WB) prescreening tool, (2) an open house initiative (OHI), (3) a primary care-based protocol for early detection of cognitive decline (PC), and (4) a tertiary care-based pre-screening at diabetologist clinics (DC). A total of 1129 patients at high risk of having prodromal AD or dementia were identified of 2847 pre-screened individuals (39. 7%). The corresponding proportion for the different initiatives were 36. 8% (WB), 35. 6% (OHI), 44. 4% (PC), and 58. 3% (DC). These four complementary pre-screening strategies were useful for identifying individuals at high risk of having prodromal or mild AD.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Alzheimer's disease ; Diagnostic gap ; Early diagnosis ; Patient engagement ; Population-based screening
Publicat a:	Alzheimer's & Dementia, Vol. 18 (july 2021) , p. 1119-1127, ISSN 1552-5279

DOI: 10.1002/alz.12441
PMID: 34310061

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