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Página principal > Artículos > Artículos publicados > Nanoceria as Safe Contrast Agents for X-ray CT Imaging |
Fecha: | 2023 |
Resumen: | Cerium oxide nanoparticles (CeONPs) have exceptional catalytic properties, rendering them highly effective in removing excessive reactive oxygen species (ROS) from biological environments, which is crucial in safeguarding these environments against radiation-induced damage. Additionally, the Ce atom's high Z number makes it an ideal candidate for utilisation as an X-ray imaging contrast agent. We herein show how the injection of albumin-stabilised 5 nm CeONPs into mice revealed substantial enhancement in X-ray contrast, reaching up to a tenfold increase at significantly lower concentrations than commercial or other proposed contrast agents. Remarkably, these NPs exhibited prolonged residence time within the target organs. Thus, upon injection into the tail vein, they exhibited efficient uptake by the liver and spleen, with 85% of the injected dose (%ID) recovered after 7 days. In the case of intratumoral administration, 99% ID of CeONPs remained within the tumour throughout the 7-day observation period, allowing for observation of disease dynamics. Mass spectrometry (ICP-MS) elemental analysis confirmed X-ray CT imaging observations. |
Ayudas: | Agencia Estatal de Investigación RTI2018-099965-B-I00 Agencia Estatal de Investigación PCI2019-103436 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-1431 Ministerio de Economía y Competitividad SEV-2017-0706 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Nanoceria ; CeO nanoparticles ; X-ray CT imaging ; Reactive oxygen species scavengers |
Publicado en: | Nanomaterials, Vol. 13, Issue 15 (August 2023) , art. 2208, ISSN 2079-4991 |
13 p, 1.9 MB |