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Pàgina inicial > Articles > Articles publicats > Lithium halide filled carbon nanocapsules : |
Data: | 2023 |
Resum: | Neutron capture therapy (NCT) is a form of radiotherapy that exploits the potential of some specific isotopes to capture thermal neutrons and subsequently yield high linear energy transfer (LET) particles, suitable for cancer treatment. Recently, relevant technological improvements have been made in terms of accelerators as suitable neutron sources for NCT at hospitals. However, low selective delivery of current drugs to cancer cells remains as the main challenge for successful clinical application of NCT. This work presents an innovative and previously unexplored approach for the design of nanotherapeutic NCT agents. Herein, a new concept based on carbon nanomaterials that seal Li active NCT nuclides is investigated. The Li active species are located in the inner cavity of the nanocarrier (carbon nanohorns or carbon nanotubes) and therefore, completely protected from the biological environment, avoiding toxicity and degradation. After encapsulation of the active cargo, the external surface of the nanocarrier is modified for improved biocompatibility. The developed Li-filled carbon nanohorns offered the possibility to explore Li compounds as active NCT agents by delivering therapeutic doses to cancer cells. We envisage that nanoencapsulation of Li can trigger the successful development and implementation of Lithium Neutron Cancer Therapy (LiNCT). |
Ajuts: | European Commission 725743 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-327 Agència de Gestió d'Ajuts Universitaris i de Recerca 2021/SGR-00439 Ministerio de Economía y Competitividad CEX2019-000917-S Ministerio de Economía y Competitividad CEX2021-001214-S |
Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Llengua: | Anglès |
Document: | Article ; recerca ; Versió publicada |
Publicat a: | Carbon, Vol. 208 (May 2023) , p. 148-159, ISSN 0008-6223 |
12 p, 9.1 MB |