Update on the effects of antioxidants on diabetic retinopathy : In vitro experiments, animal studies and clinical trials
Garcia-Medina, Jose Javier (Instituto de Salud Carlos III)
Rubio-Velazquez, Elena (Hospital General Universitario Morales Meseguer (Múrcia))
Foulquie-Moreno, Elisa (Hospital General Universitario Morales Meseguer (Múrcia))
Casaroli-Marano, Ricardo Pedro (Institut d'Investigació Biomèdica Sant Pau)
Pinazo-Duran, Maria Dolores (Instituto de Salud Carlos III)
Zanón-Moreno, Vicente (Universidad Internacional de Valencia (VIU))
Del-Rio-vellosillo, Monica (Hospital Universitario Virgen de la Arrixaca (Múrcia))
Universitat Autònoma de Barcelona

Date:	2020
Abstract:	Current therapies for diabetic retinopathy (DR) incorporate blood glucose and blood pressure control, vitrectomy, photocoagulation, and intravitreal injections of anti-vascular endothelial growth factors or corticosteroids. Nonetheless, these techniques have not been demonstrated to completely stop the evolution of this disorder. The pathophysiology of DR is not fully known, but there is more and more evidence indicating that oxidative stress is an important mechanism in the progression of DR. In this sense, antioxidants have been suggested as a possible therapy to reduce the complications of DR. In this review we aim to assemble updated information in relation to in vitro experiments, animal studies and clinical trials dealing with the effect of the antioxidants on DR.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Animal ; Antioxidant ; Cell ; Clinical trial ; Diabetic retinopathy ; Human ; In vitro ; Oxidative stress ; Patient ; Retina
Published in:	Antioxidants, Vol. 9 Núm. 6 (2020) , p. 1-23, ISSN 2076-3921

DOI: 10.3390/ANTIOX9060561
PMID: 32604941

23 p, 384.1 KB

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