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| Pàgina inicial > Articles > Articles publicats > Glycoprotein profile assessed by1h-nmr as a global inflammation marker in patients with HIV infection. A prospective study |
(Universitat Rovira i Virgili) (Institut d'Investigació Biomèdica Sant Pau) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili) (Universitat Rovira i Virgili)| Data: | 2020 |
| Resum: | Plasma glycoproteins are a composite biomarker of inflammation and can be detected byH-NMR. The aim of this study was to prospectively appraise the clinical value of plasma glycopro-teins assessed byH-NMR in people living with HIV (PLWH). A total of 221 patients with HIV infection were recruited and studied at baseline and at 48 and 144 weeks. Patients were distributed into two groups according to baseline CD4 T-cell number below or above 200 cells/µL. Patients with fewer than 200 cells/µL were distributed into the responders and nonresponders according to antiretroviral therapy (ART) response at 144 weeks. Glycoprotein concentrations were determined byH-NMR arising from the protein bond N-acetylglucosamine and N-acetylgalactosamine signals (GlycA); and N-acetylneuraminic acid signal (GlycB) associated with the sugar-protein bond con-centration and aggregation state (shapes (height/width)). Basal glycoprotein concentrations were higher in patients with < 200 CD4 T-cell/µL (Glyc A: 1040(917. 9-1199. 1) vs. 950. 4(845. 5-1050. 9), p < 0. 001, and Glyc B: 521(440. 3-610. 3) vs. 468. 6(417. 9-507. 0) µ mol/L, p < 0. 001) being reduced by ART. The height/width (H/W) ratio was the parameter showing a better association with this clinical sta-tus. Baseline glycoproteins predict the condition of responder/nonresponder. In this study,H-NMR glycoproteins provide novel insights to assess inflammation status and have prognostic value in PLWH. |
| Ajuts: | Ministerio de Economía y Competitividad PI13/00796 Ministerio de Economía y Competitividad PI16/00503 Instituto de Salud Carlos III PI19/01337 Ministerio de Economía y Competitividad RD16/0025/0006 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Glycoprotein ; HIV-1 ; Immunological responders ; Inflammation ; Proton nuclear magnetic resonance (1H-NMR) |
| Publicat a: | Journal of clinical medicine, Vol. 9 Núm. 5 (may 2020) , p. 1344, ISSN 2077-0383 |
