The Weak Relationship between Vitamin D Compounds and Glucose Homeostasis Measures in Pregnant Women with Obesity : An Exploratory Sub-Analysis of the DALI Study
Mendoza, Lilian Cristina (Institut d'Investigació Biomèdica Sant Pau)
Harreiter, Jürgen (Clinical Division of Endocrinology and Metabolism. Department of Internal Medicine III. Gender Medicine Unit. Medical University of Vienna)
Desoye, Gernot (Department of Obstetrics and Gynecology. Medical University of Graz)
Simmons, David (Macarthur Clinical School. School of Medicine. Western Sydney University)
Adelantado, Juan M.. (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Kautzky-Willer, Alexandra (Clinical Division of Endocrinology and Metabolism. Department of Internal Medicine III. Gender Medicine Unit. Medical University of Vienna)
Zawiejska, Agnieszka (Department of Reproduction. Poznan University of Medical Sciences)
Wender-Ozegowska, Ewa (Department of Reproduction. Poznan University of Medical Sciences)
Lapolla, A. (Department of Medicine. University of Padova)
Dalfra, Maria Grazia (Università Degli Studi di Padova)
Bertolotto, Alessandra (Department of Clinical and Experimental Medicine. University of Pisa)
Devlieger, Roland (Obstetrics and Gynecology. University Hospitals KU Leuven)
Dunne, Fidelma (College of Medicine. Nursing and Health Sciences. School of Medicine. National University of Ireland)
Mathiesen, E.R. (Center for Pregnant Women with Diabetes. Departments of Endocrinology and Obstetrics. Rigshospitalet. University of Copenhagen)
Damm, Peter (Center for Pregnant Women with Diabetes. Departments of Endocrinology and Obstetrics. Rigshospitalet. University of Copenhagen)
Andersen, Lise-Lotte (Department of Gynecology and Obstetrics. Odense University Hospital)
Jensen, Dorte M (Department of Gynecology and Obstetrics. Odense University Hospital)
Hill, David J (Lawson Health Research Institute. St. Joseph Health Care)
van Poppel, M.N.M. (Institute of Sport Science. University of Graz)
Corcoy i Pla, Rosa (Institut d'Investigació Biomèdica Sant Pau)
Universitat Autònoma de Barcelona

Data:	2022
Resum:	Studies on the relationship between vitamin D (VitD) and glucose homeostasis usually consider either total VitD or 25OHD3 but not 25OHD2 and epimers. We aimed to evaluate the cross-sectional association of VitD compounds with glucose homeostasis measurements in pregnant women with overweight/obesity participating in the Vitamin D And Lifestyle Intervention for Gestational Diabetes Mellitus Prevention study. Methods: The analysis included 912 women. Inclusion criteria: <20 weeks gestation, body mass index ≥29 kg/m and information on exposure and outcome variables at baseline. Measurements: A 75 g OGTT at <20, 24-28 and 35-37 weeks gestation (except if previous diabetes diagnosis). Exposure variables: 25OHD2, 25OHD3 and C3-epimer. Outcome variables: fasting and post-challenge insulin sensitivity and secretion indices, corresponding disposition indices (DI), plasma glucose at fasting and 1 and 2 h, hyperglycemia in pregnancy (HiP). Statistics: Multivariate regression analyses with adjustment. Results: Baseline VitD sufficiency was 66. 3%. Overall, VitD compounds did not show strong associations with any glucose homeostasis measures. 25OHD3 showed direct significant associations with: FPG at <20 and 24-28 weeks (standardized β coefficient (β) 0. 124, p = 0. 030 and 0. 111, p = 0. 026 respectively), 2 h plasma glucose at 24-28 weeks (β 0. 120, p = 0. 018), and insulin sensitivity (1/HOMA-IR, β 0. 127, p = 0. 027) at 35-37 weeks; it showed an inverse association with fasting DI (QUCKI*HOMA-β) at <20 and 24-28 weeks (β −0. 124, p = 0. 045 and β −0. 148, p = 0. 004 respectively). 25OHD2 showed direct associations with post-challenge insulin sensitivity (Matsuda, β 0. 149, p = 0. 048) at 24-28 weeks) and post-challenge DI (Matsuda*Stumvoll phase 1) at 24-28 and 35-37 weeks (β 0. 168, p = 0. 030, β 0. 239, p = 0. 006). No significant association with C3-epimer was observed at any time period. Conclusions: In these women with average baseline VitD in sufficiency range, VitD compounds did not show clear beneficial associations with glucose homeostasis measures.
Ajuts:	European Commission 242187
Nota:	Altres ajuts: Netherlands Organization for Health Research and Development (ZonMw, 200310013); Polish Ministry of Science (2203/7, PR/2011/2); Odense University Free Research Fund; NIHR Clinical Research Network: Eastern; In Spain (CAIBER 1527-B-226); Spanish Diabetes Society (SED) XI Grant for clinical research projects in diabetes.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Vitamin D compounds ; 25OHD2 ; 25OHD3 ; C3-epimer ; Glucose homeostasis ; Pregnancy ; Obesity
Publicat a:	Nutrients, Vol. 14 Núm. 16 (august 2022) , p. 3256, ISSN 2072-6643

DOI: 10.3390/nu14163256
PMID: 36014761

13 p, 570.9 KB

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