Metagenomic insight into the global dissemination of the antibiotic resistome
Zhang, Qi (Zhejiang University of Technology. College of Environment)
Xu, Nuohan (Zhejiang University of Technology. College of Environment)
Lei, Chaotang (Zhejiang University of Technology. College of Environment)
Chen, Bingfeng (Zhejiang University of Technology. College of Environment)
Wang, Tingzhang (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province)
Ma, Yunting (Key Laboratory of Microbial Technology and Bioinformatics of Zhejiang Province)
Lu, Tao (Zhejiang University of Technology. College of Environment)
Peñuelas, Josep (Centre de Recerca Ecològica i d'Aplicacions Forestals)
Gillings, Michael (Macquarie University. School of Natural Sciences)
Zhu, Yong-Guan (Chinese Academy of Sciences. Institute of Urban Environment)
Fu, Zhengwei (Zhejiang University of Technology. College of Environment)
Qian, Haifeng (Zhejiang University of Technology. College of Environment)

Data:	2023
Resum:	The global crisis in antimicrobial resistance continues to grow. Estimating the risks of antibiotic resistance transmission across habitats is hindered by the lack of data on mobility and habitat-specificity. Metagenomic samples of 6092 are analyzed to delineate the unique core resistomes from human feces and seven other habitats. This is found that most resistance genes (≈85%) are transmitted between external habitats and human feces. This suggests that human feces are broadly representative of the global resistome and are potentially a hub for accumulating and disseminating resistance genes. The analysis found that resistance genes with ancient horizontal gene transfer (HGT) events have a higher efficiency of transfer across habitats, suggesting that HGT may be the main driver for forming unique but partly shared resistomes in all habitats. Importantly, the human fecal resistome is historically different and influenced by HGT and age. The most important routes of cross-transmission of resistance are from the atmosphere, buildings, and animals to humans. These habitats should receive more attention for future prevention of antimicrobial resistance. The study will disentangle transmission routes of resistance genes between humans and other habitats in a One Health framework and can identify strategies for controlling the ongoing dissemination and antibiotic resistance.
Ajuts:	Ministerio de Ciencia e Innovación TED2021-132627B-I00
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Antibiotic resistome ; Horizontal gene transfer ; Metadata ; Metagenome ; One health
Publicat a:	Advanced science, First published 23 October 2023, art. 2303925, ISSN 2198-3844

DOI: 10.1002/advs.202303925
PMID: 37870180

11 p, 3.2 MB

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