HTLV-1 infection in solid organ transplant donors and recipients in Spain
De Mendoza, Carmen (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Roc, Lourdes (Hospital Universitario Miguel Servet (Saragossa))
Benito, Rafael (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Reina, Gabriel (Clínica Universidad de Navarra)
Ramos, Jose Manuel (Hospital General Universitario de Alicante (Alacant, País Valencià))
Gómez, Cesar (Complejo Hospitalario de Toledo)
Aguilera, Antonio ((Hospital Conxo-CHUS (Santiago))
Rodríguez-Iglesias, Manuel Antonio (Hospital Universitario de Puerto Real (Cadis, Andalusia))
García-Costa, Juan (Complejo Hospitalario Universitario de Ourense)
Fernández-Alonso, Miriam (Clínica Universidad de Navarra)
Soriano, Vicente (UNIR Health Sciences School & Medical Centre (Madrid))
Rodríguez, Carmen (Centro Sanitario Sandoval)
Vera, Mar (Centro Sanitario Sandoval)
Del Romero, Jorge (Centro Sanitario Sandoval)
Marcaida, Goitzane (Hospital General Universitario de Valencia)
Ocete, María Dolores (Hospital General Universitario de Valencia)
Caballero Requero, Estrella (Hospital Universitari Vall d'Hebron)
Molina Romero, Israel (Hospital Universitari Vall d'Hebron)
Rodríguez-Calviño, Juan J. (Hospital Conxo-CHUS (Santiago))
Navarro, Daniel (Hospital Conxo-CHUS (Santiago))
Rivero, Constanza (Hospital Conxo-CHUS (Santiago))
Vilariño, M.D. (Hospital Conxo-CHUS (Santiago))
Benito, Rafael (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Algarate, S. (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Gil, Joaquina (Hospital Clínico Universitario "Lozano Blesa" de Zaragoza)
Ortiz de Lejarazu, Raúl (Hospital Clínico Universitario de Valladolid)
Rojo, Silvia (Hospital Clínico Universitario de Valladolid)
Eirós, José M.
San Miguel, A.
Manzardo, Christian
Miró, José M
García, Juan
Paz, Irmia
Poveda, Eva
Calderón, Enrique J.
Escudero, Domingo
Trigo-Daporta, Matilde
Diz, Julio
García-Campello, Marta
Rodríguez Iglesias, Manuel
Hernández Betancor, Araceli Pascual
Martín, Antonio Manuel
Ramos, José Manuel
Gimeno Gascon, Adelina
Gutiérrez, Félix
Rodríguez, Juan Carlos
Sánchez, V.
Gómez Hernando, Cesar
Cilla, Gustavo
Pérez-Trallero, Emilio
López Aldeguer, Jose
Fernández Pereira, Luis
Niubó, Jordi
Hernández, M.
López Lirola, Ana María
Gómez Sirvent, Juan Luis
Force, Lluís L.
Cifuentes, Carmen
Pérez-Castro, Sonia
Morano, Luís Enrique
Raya, Carmen
González Praetorius, Alejandro
Pérez, Jose Luis
Peñaranda Vera, Maria (Hospital Universitari Son Espases (Palma de Mallorca, Balears))
Hernáez Crespo, Silvia (Hospital Universitario de Basurto (Bilbao))
Montejo, Jose Miguel (Hospital de Cruces (Barakaldo, Biscaia))
Roc, Lourdes (Hospital Universitario Miguel Servet (Saragossa))
Martínez Sapiña, Ana (Hospital Universitario Miguel Servet (Saragossa))
Viciana, Isabel (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Cabezas, Teresa (Hospital de Poniente (Almería))
Lozano, Ana Belén (Hospital de Poniente (Almería))
Fernández, J.M. (Hospital de Poniente (Almería))
García-Bermejo, Isabel (Hospital Universitario de Getafe)
Gaspar Alonso-Vega, Gabriel (Hospital Universitario de Getafe)
García, R. (Hospital Universitario Fundación Jiménez Díaz)
Górgolas Hernandez-Mora, Miguel (Hospital Universitario Fundación Jiménez Díaz)
Vegas, C. (Hospital Universitario Fundación Jiménez Díaz)
Blas, J. (Hospital Universitario Fundación Jiménez Díaz)
Miralles, Pilar (Hospital General Universitario Gregorio Marañón)
Valeiro, M. (Hospital General Universitario Gregorio Marañón)
Aldamiz, T. (Hospital General Universitario Gregorio Marañón)
Margall, Núria (Institut d'Investigació Biomèdica Sant Pau)
Guardia, C. (ICS (Barcelona))
Do Pico, E. (ICS (Barcelona))
Polo, I. (Complejo Hospitalario de Navarra)
Aguinaga, A. (Complejo Hospitalario de Navarra)
Ezpeleta, C. (Complejo Hospitalario de Navarra)
Sauleda, Silvia (Banco de Sangre & Tejidos (Barcelona))
Piron, Maria (Banco de Sangre & Tejidos (Barcelona))
González, R. (Centro de Transfusiones (Madrid))
Barea, L. 4u Centro de Transfusiones (Madrid)
Jiménez, A. (Centro de Hemoterapia y Hemodonación de Castilla y León (Valladolid))
Blanco, L. (Centro de Hemoterapia y Hemodonación de Castilla y León (Valladolid))
Suárez, A. (Hospital Clínico San Carlos (Madrid))
Avial, I.R. (Hospital Clínico San Carlos (Madrid))
Rivilla, A.P. Hospital Universitario 12 de Octubre (Madrid)
Parra, P. (Hospital Universitario 12 de Octubre (Madrid))
Fernández-Alonso, M. (Clínica Universitaria de Navarra (Pamplona))
Treviño, A. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Requena, S. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Gutiérrez, L.B. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Mons, V.C. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
De Mendoza, C. (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Barreiro, P. (Hospital Universitario La Paz (Madrid))
Corral, O. (UNIR Health Sciences School & Medical Centre (Madrid))
Gomez-Gallego, Felix
Universitat Autònoma de Barcelona

Data:	2019
Resum:	HTLV-1 infection is a neglected disease, despite infecting 10-15 million people worldwide and severe illnesses develop in 10% of carriers lifelong. Acknowledging a greater risk for developing HTLV-1 associated illnesses due to immunosuppression, screening is being widely considered in the transplantation setting. Herein, we report the experience with universal HTLV testing of donors and recipients of solid organ transplants in a survey conducted in Spain. All hospitals belonging to the Spanish HTLV network were invited to participate in the study. Briefly, HTLV antibody screening was performed retrospectively in all specimens collected from solid organ donors and recipients attended since the year 2008. A total of 5751 individuals were tested for HTLV antibodies at 8 sites. Donors represented 2312 (42. 2%), of whom 17 (0. 3%) were living kidney donors. The remaining 3439 (59. 8%) were recipients. Spaniards represented nearly 80%. Overall, 9 individuals (0. 16%) were initially reactive for HTLV antibodies. Six were donors and 3 were recipients. Using confirmatory tests, HTLV-1 could be confirmed in only two donors, one Spaniard and another from Colombia. Both kidneys of the Spaniard were inadvertently transplanted. Subacute myelopathy developed within 1 year in one recipient. The second recipient seroconverted for HTLV-1 but the kidney had to be removed soon due to rejection. Immunosuppression was stopped and 3 years later the patient remains in dialysis but otherwise asymptomatic. The rate of HTLV-1 is low but not negligible in donors/recipients of solid organ transplants in Spain. Universal HTLV screening should be recommended in all donor and recipients of solid organ transplantation in Spain. Evidence is overwhelming for very high virus transmission and increased risk along with the rapid development of subacute myelopathy.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adult T-cell leukaemia ; HTLV-1 ; Immunosuppression ; Screening ; Transplantation ; Tropical spastic paraparesis
Publicat a:	BMC Infectious diseases, Vol. 19 Núm. 1 (september 2019) , p. 706, ISSN 1471-2334

DOI: 10.1186/s12879-019-4346-z
PMID: 31399112

5 p, 548.5 KB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències de la salut i biociències > Institut de Recerca Sant Pau
Articles > Articles de recerca
Articles > Articles publicats